Update: Innate Lymphoid Cells in Inflammatory Bowel Disease

被引：46

作者：

Luo, Weiwei ^{[1
,2
]}

Tian, Li ^{[1
]}

Tan, Bei ^{[3
]}

Shen, Zhaohua ^{[1
,2
]}

Xiao, Mengwei ^{[1
,2
]}

Wu, Shuai ^{[1
,2
]}

Meng, Xiangrui ^{[1
,2
]}

Wu, Xing ^{[1
,2
]}

Wang, Xiaoyan ^{[1
,2
]}

机构：

[1] Cent South Univ, Dept Gastroenterol, Xiangya Hosp 3, Tongzipo Rd, Changsha 410013, Hunan, Peoples R China

[2] Hunan Key Lab Non Resolving Inflammat & Canc, Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[3] Changsha Med Univ, Dept Gastroenterol, Hosp 1, Yingpan Rd, Changsha 410005, Hunan, Peoples R China

来源：

DIGESTIVE DISEASES AND SCIENCES | 2022年 / 67卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Inflammatory bowel disease; Innate lymphoid cells; Natural killer cells; CD4-positive T-lymphocytes; Microbiota; Biological therapy;

D O I：

10.1007/s10620-021-06831-8

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel disease (IBD) is a chronic and nonspecific intestinal inflammatory condition with high relapse rate. Its pathogenesis has been linked to dysbacteriosis, genetic and environmental factors. In recent years, a new type of lymphocytes, termed innate lymphoid cells, has been described and classified into three subtypes of innate lymphoid cells-group 1, group 2 and group 3. An imbalance among these subsets' interaction with gut microbiome, and other immune cells affects intestinal mucosal homeostasis. Understanding the role of innate lymphoid cells may provide ideas for developing novel and targeted approaches for treatment of IBD.

引用

页码：56 / 66

页数：11

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