Isoeugenitol, a cyclooxygenase-1 inhibitor from Gethyllis ciliaris

被引：11

作者：

Elgorashi, E. E.

Coombes, P. H.

Mulholland, D. A.

Van Staden, J.

机构：

[1] Univ KwaZulu Natal Pietermaritzburg, Sch Biol & Conservat Sci, Res Ctr Plant Growth & Dev, ZA-3209 Scottsville, South Africa

[2] Univ KwaZulu Natal, Sch Chem, ZA-4001 Durban, South Africa

来源：

SOUTH AFRICAN JOURNAL OF BOTANY | 2007年 / 73卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Amaryllidaceae; anti-inflammatory; COX-1; Gethyllis ciliaris; isoeugenitol; isoeugenitol glycoside;

D O I：

10.1016/j.sajb.2006.06.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay guided fractionation of the dichloromethane extract of the underground parts of Gethyllis ciliaris, using a cyclooxygenase-1 enzyme assay, has resulted in the isolation of the dihydroxydimethylbenzopyran-4-one isoeugenitol 1 (IC50 = 262 mu M). The 90% methanolic extract yielded 9Z-octadec-9-enamide 3 and the novel compound isoeugenitol glycoside 2. The structures of the isolated compounds have been assigned on the basis of spectral analysis, including 1D and 2D NMR techniques. (c) 2006 SAAB. Published by Elsevier B.V. All rights reserved.

引用

页码：156 / 158

页数：3

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