mTOR signaling at a glance

被引:1761
作者
Laplante, Mathieu [1 ,2 ]
Sabatini, David M. [1 ,2 ,3 ]
机构
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[2] MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA
[3] MIT, Koch Ctr Integrat Canc Res, Cambridge, MA 02139 USA
关键词
TUBEROUS SCLEROSIS COMPLEX; MESSENGER-RNA TRANSLATION; TUMOR-SUPPRESSOR COMPLEX; IKK-BETA SUPPRESSION; MAMMALIAN TARGET; CELL-GROWTH; AMINO-ACIDS; BINDING PARTNER; PROTEIN-KINASE; RAPAMYCIN MTOR;
D O I
10.1242/jcs.051011
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:3589 / 3594
页数:6
相关论文
共 70 条
[1]   A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets [J].
Arsham, AM ;
Howell, JJ ;
Simon, MC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (32) :29655-29660
[2]   Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy [J].
Bentzinger, C. Florian ;
Romanino, Klaas ;
Cloetta, Dimitri ;
Lin, Shuo ;
Mascarenhas, Joseph B. ;
Oliveri, Filippo ;
Xia, Jinyu ;
Casanova, Emilio ;
Costa, Celine F. ;
Brink, Marijke ;
Zorzato, Francesco ;
Hall, Michael N. ;
Rueegg, Markus A. .
CELL METABOLISM, 2008, 8 (05) :411-424
[3]   PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR [J].
Bernardi, Rosa ;
Guernah, Ilhem ;
Jin, David ;
Grisendi, Silvia ;
Alimonti, Andrea ;
Teruya-Feldstein, Julie ;
Cordon-Cardo, Carlos ;
Simon, M. Celeste ;
Rafii, Shahin ;
Pandolfi, Pier Paolo .
NATURE, 2006, 442 (7104) :779-785
[4]   Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex [J].
Brugarolas, J ;
Lei, K ;
Hurley, RL ;
Manning, BD ;
Reiling, JH ;
Hafen, E ;
Witter, LA ;
Ellisen, LW ;
Kaelin, WG .
GENES & DEVELOPMENT, 2004, 18 (23) :2893-2904
[5]   The FoxO code [J].
Calnan, D. R. ;
Brunet, A. .
ONCOGENE, 2008, 27 (16) :2276-2288
[6]   TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species [J].
Chen, Chong ;
Liu, Yu ;
Liu, Runhua ;
Ikenoue, Tsuneo ;
Guan, Kun-Liang ;
Liu, Yang ;
Zheng, Pan .
JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (10) :2397-2408
[7]   Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation [J].
Choo, Andrew Y. ;
Yoon, Sang-Oh ;
Kim, Sang Gyun ;
Roux, Philippe P. ;
Blenis, John .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (45) :17414-17419
[8]   Autophagy and signaling: their role in cell survival and cell death [J].
Codogno, P ;
Meijer, AJ .
CELL DEATH AND DIFFERENTIATION, 2005, 12 (Suppl 2) :1509-1518
[9]   The tuberous sclerosis complex [J].
Crino, Peter B. ;
Nathanson, Katherine L. ;
Henske, Elizabeth Petri .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (13) :1345-1356
[10]   mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex [J].
Cunningham, John T. ;
Rodgers, Joseph T. ;
Arlow, Daniel H. ;
Vazquez, Francisca ;
Mootha, Vamsi K. ;
Puigserver, Pere .
NATURE, 2007, 450 (7170) :736-U12