Multicomponent Synthesis of Unsymmetrical 4,5-Disubstituted Imidazolium Salts as N-Heterocyclic Carbene Precursors: Applications in Palladium-Catalyzed Cross-Coupling Reactions

被引：6
|
作者：
Wang, Jiwei [1 ,2 ,3 ]
Cheng, Xiang [2 ,3 ]
Liu, Ye [1 ]
Zhang, Jun [2 ,3 ]
机构：
[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
[2] East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China
[3] East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn, Shanghai 200237, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 09期
基金：
中国国家自然科学基金;
关键词：
NHC COMPLEXES; LIGANDS; CHLORIDES; REAGENTS; OLEFINS; GOLD;
D O I：
10.1021/acs.joc.1c00075
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Various novel (a)chiral 4,5-disubstituted 1-aryl-3-alkyl-imidazolium salts were synthesized via the multicomponent reaction of diketone derivatives, sterically congested arylamines, and alkylamines. Moreover, two novel unsymmetrical bulky cycloalkyl-based NHC-Pd complexes proved highly active as catalysts for Suzuki-Miyaura and Negishi cross-coupling reactions.
引用
收藏
页码：6278 / 6288
页数：11
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