Rapid genotype analysis of the matrix metalloproteinase-1 gene 1G/2G polymorphism that is associated with risk of cancer

被引：42

作者：

Dunleavey, L ^{[1
]}

Beyzade, S ^{[1
]}

Ye, S ^{[1
]}

机构：

[1] Univ Southampton, Dept Human Genet, Southampton SO16 6YD, Hants, England

来源：

MATRIX BIOLOGY | 2000年 / 19卷 / 02期

关键词：

interstitial collagenase; polymorphism; cancer;

D O I：

10.1016/S0945-053X(00)00059-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A bi-allelic polymorphism in the promoter of the human matrix metalloproteinase-l gene has been reported. It has been found to have a functional effect on the promoter strength and to be associated with risk of cancers. The polymorphism is due to an insertion/deletion of a guanine, and conventional methodologies for genotyping this polymorphism are time-consuming and expensive. A rapid genotyping method based on restriction endonuclease digestion is reported here. (C) 2000 Elsevier Science B.V. /International Society of Matrix Biology. All rights reserved.

引用

页码：175 / 177

页数：3

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