RETRACTED: Dobera glabra (Forssk.) Poir. (Salvadoraceae); phenolic constituents of the aqueous leaves extract and evaluation of its anti-inflammatory, analgesic activities (Retracted Article)

被引：6

作者：

Emam, Mahmoud ^{[1
,2
,3
]}

Moustafa, Passant E. ^{[4
]}

Elkhateeb, Ahmed ^{[3
]}

Hussein, Sameh R. ^{[3
]}

Marzouk, Mona M. ^{[3
]}

Abd El-Rahman, Sahar S. ^{[5
]}

Abdel-Hameed, El-Sayed S. ^{[6
]}

Abdel-Rahman, Rehab F. ^{[4
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

[2] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China

[3] Natl Res Ctr, Dept Phytochem & Plant Systemat, 33 El Bohouth St,PO 12622, Giza, Egypt

[4] Natl Res Ctr, Dept Pharmacol, Med Res Div, Giza, Egypt

[5] Cairo Univ, Fac Vet Med, Dept Pathol, Giza, Egypt

[6] Theodor Bilharz Res Inst, Lab Med Chem, Giza, Egypt

来源：

HELIYON | 2021年 / 7卷 / 02期

关键词：

Dobera glabra; Anti-Inflammatory; Analgesic; Flavonoids; Rat; PAW EDEMA; HIND PAW; FLAVONOIDS; ACID; ANTIOXIDANT; ACTIVATION; GLYCOSIDES; INHIBITOR; PLANTS;

D O I：

10.1016/j.heliyon.2021.e06205

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: The plant kingdom is considered one of the most common sources for structural and biological diversity. In particular, the wild category acquires our attention to investigate the phytochemical and the biological evaluations. Methods: Dobera glabra was exposed to phytochemical examination using HPLC-ESI-MS analysis. Furthermore, the anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema model, whereas both the central and peripheral analgesic activities were tested via hot plate test in rats and acetic acid-induced writhing in mice, respectively. Results: Twenty phenolic compounds of D. glabra aqueous leaves extract were emphasized by liquid chromatography coupled with mass spectrometry. Moreover, D. glabra exhibited both anti-inflammatory and peripheral analgesic activities. Furthermore, D. glabra significantly decreased the immune expression of MMP-9, TNF-alpha and TGF-beta 1 in the hind paw of rats. Conclusion: D. glabra possess peripheral anti-nociceptive and anti-inflammatory effects in rats mediated through its anti-oxidant and anti-inflammatory activities. The activity of D. glabra leaves extract might be attributed to the presence of hydroxy and keto structures.

引用

页数：13