Oxidative Sulfonylation of Hydrazones Enabled by Synergistic Copper/Silver Catalysis

被引：21

作者：

Xu, Jun ^{[1
,2
,3
]}

Shen, Chao ^{[4
]}

Qin, Xian ^{[1
,2
]}

Wu, Jie ^{[1
,2
,3
]}

Zhang, Pengfei ^{[4
]}

Liu, Xiaogang ^{[1
,2
,3
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Natl Univ Singapore, N1 Inst Hlth, Singapore 117543, Singapore

[3] Natl Univ Singapore, Ctr Funct Mat, Suzhou Res Inst, Suzhou 215123, Peoples R China

[4] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 311121, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 05期

基金：

新加坡国家研究基金会; 中国国家自然科学基金;

关键词：

D O I：

10.1021/acs.joc.0c02249

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper/silver-cocatalyzed protocol for oxidative sulfonylation of hydrazones is demonstrated. A wide range of beta-ketosulfones and N-acylsulfonamides are directly synthesized in moderate to good yields. Our work provides a viable method for scalable preparation of beta-ketosulfone derivatives that have found wide applications in the pharmaceutical industry.

引用

页码：3706 / 3720

页数：15

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