A proposal for a new clinical classification of chronic pancreatitis

被引:58
作者
Buechler, Markus W. [1 ]
Martignoni, Marc E. [2 ]
Friess, Helmut [2 ]
Malfertheiner, Peter [3 ]
机构
[1] Heidelberg Univ, Dept Gen Surg, D-6900 Heidelberg, Germany
[2] Tech Univ Munich, Dept Surg, D-8000 Munich, Germany
[3] Otto VonGuericke Univ Magdegurg, Dept Gastroenterol & Infect Dis, D-39016 Magdeburg, Germany
关键词
ALCOHOLIC CHRONIC-PANCREATITIS; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; PRESERVING HEAD RESECTION; CENTER 26-YEAR EXPERIENCE; QUALITY-OF-LIFE; STELLATE CELLS; NATURAL COURSE; PAIN; MANAGEMENT; DISEASE;
D O I
10.1186/1471-230X-9-93
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: The clinical course of chronic pancreatitis is still unpredictable, which relates to the lack of the availability of a clinical classification. Therefore, patient populations cannot be compared, the course and the outcome of the disease remain undetermined in the individual patient, and treatment is not standardized. Aim: To establish a clinical classification for chronic pancreatitis which is user friendly, transparent, relevant, prognosis-as well as treatment-related and offers a frame for future disease evaluation. Methods: Diagnostic requirements will include one clinical criterion, in combination with well defined imaging or functional abnormalities. Results: A classification system consisting of three stages (A, B and C) is presented, which fulfils the above-mentioned criteria. Clinical criteria are: pain, recurrent attacks of pancreatitis, complications of chronic pancreatitis (e. g. bile duct stenosis), steatorrhea, and diabetes mellitus. Imaging criteria consist of ductal or parenchymal changes observed by ultrasonography, ERCP, CT, MRI, and/or endosonography. Conclusion: A new classification of chronic pancreatitis, based on combination of clinical signs, morphology and function, is presented. It is easy to handle and an instrument to study and to compare the natural course, the prognosis and treatment of patients with chronic pancreatitis.
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页数:8
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