Chemoreceptor mechanisms regulating CO2-induced arousal from sleep

被引：11

作者：

Abbott, Stephen B. G. ^{[1
]}

Souza, George M. P. R. ^{[1
]}

机构：

[1] Univ Virginia, Dept Pharmacol, 1340 Jefferson Pk Ave, Charlottesville, VA 29903 USA

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2021年 / 599卷 / 10期

基金：

美国国家卫生研究院;

关键词：

arousal threshold; interoception; obstructive sleep apnea; optogenetic; respiration; sleep‐ wake behavior;

D O I：

10.1113/JP281305

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Arousal from sleep in response to CO2 is a life-preserving reflex that enhances ventilatory drive and facilitates behavioural adaptations to restore eupnoeic breathing. Recurrent activation of the CO2-arousal reflex is associated with sleep disruption in obstructive sleep apnoea. In this review we examine the role of chemoreceptors in the carotid bodies, the retrotrapezoid nucleus and serotonergic neurons in the dorsal raphe in the CO2-arousal reflex. We also provide an overview of the supra-medullary structures that mediate CO2-induced arousal. We propose a framework for the CO2-arousal reflex in which the activity of the chemoreceptors converges in the parabrachial nucleus to trigger cortical arousal.

引用

收藏

页码：2559 / 2571

页数：13

相关论文

共 116 条

[1] Phox2b-Expressing Neurons of the Parafacial Region Regulate Breathing Rate, Inspiration, and Expiration in Conscious Rats [J].

Abbott, Stephen B. G. ;

Stornetta, Ruth L. ;

Coates, Melissa B. ;

Guyenet, Patrice G. .

JOURNAL OF NEUROSCIENCE, 2011, 31 (45) :16410-16422

[2] Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome [J].

Amiel, J ;

Laudier, B ;

Attié-Bitach, T ;

Trang, H ;

de Pontual, L ;

Gener, B ;

Trochet, D ;

Etchevers, H ;

Ray, P ;

Simonneau, M ;

Vekemans, M ;

Munnich, A ;

Gaultier, C ;

Lyonnet, S .

NATURE GENETICS, 2003, 33 (04) :459-461

[3] Stimulus-response characteristics of CO2-induced air hunger in normal [J].

Banzett, RB ;

Lansing, RW ;

Evans, KC ;

Shea, SA .

RESPIRATION PHYSIOLOGY, 1996, 103 (01) :19-31

[4] Hypoxia Silences Retrotrapezoid Nucleus Respiratory Chemoreceptors via Alkalosis [J].

Basting, Tyler M. ;

Burke, Peter G. R. ;

Kanbar, Roy ;

Viar, Kenneth E. ;

Stornetta, Daniel S. ;

Stornetta, Ruth L. ;

Guyenet, Patrice G. .

JOURNAL OF NEUROSCIENCE, 2015, 35 (02) :527-543

[5] Brainstem and hypothalamic areas involved in respiratory chemoreflexes: a Fos study in adult rats [J].

Berquin, P ;

Bodineau, L ;

Gros, F ;

Larnicol, N .

BRAIN RESEARCH, 2000, 857 (1-2) :30-40

[6] Respiratory arousal from sleep: Mechanisms and significance [J].

Berry, RB ;

Gleeson, K .

SLEEP, 1997, 20 (08) :654-675

[7] Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO2 [J].

Blain, Gregory M. ;

Smith, Curtis A. ;

Henderson, Kathleen S. ;

Dempsey, Jerome A. .

JOURNAL OF PHYSIOLOGY-LONDON, 2010, 588 (13) :2455-2471

[8] Pre-Botzinger complex receives glutamatergic innervation from galaninergic and other retrotrapezoid nucleus neurons [J].

Bochorishvili, Genrieta ;

Stornetta, Ruth L. ;

Coates, Melissa B. ;

Guyenet, Patrice G. .

JOURNAL OF COMPARATIVE NEUROLOGY, 2012, 520 (05) :1047-1061

[9] Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour [J].

Bonnavion, Patricia ;

Mickelsen, Laura E. ;

Fujita, Akie ;

de Lecea, Luis ;

Jackson, Alexander C. .

JOURNAL OF PHYSIOLOGY-LONDON, 2016, 594 (22) :6443-6462

[10] Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons [J].

Bowen, Anna J. ;

Chen, Jane Y. ;

Huang, Y. Waterlily ;

Baertsch, Nathan A. ;

Park, Sekun ;

Palmiter, Richard D. .

← 1 2 3 4 5 6 7 8 9 10 →