Biocompatibility of borosilicate glass-ceramics based LTCC materials for microfluidic biosensor application

被引：4
作者：
Liang, Yongyuan [1 ,2 ]
Ma, Mingsheng [1 ]
Qian, Suxiang [1 ,2 ]
Zhuang, Hui [1 ,2 ]
Li, Kunqiang [1 ,2 ]
Liu, Zhifu [1 ]
Li, Yongxiang [1 ,3 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Ceram, CAS Key Lab Inorgan Funct Mat & Devices, Shanghai 200050, Peoples R China
[2] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing, Peoples R China
[3] RMIT Univ, Sch Engn, Melbourne, Vic, Australia
来源：
INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY | 2020年 / 17卷 / 01期
关键词：
borosilicate glass; dielectric materials; properties; glass-ceramics; IN-VITRO BIOACTIVITY; COMPOSITE; SCAFFOLDS;
D O I：
10.1111/ijac.13357
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Three kinds of borosilicate glass-ceramics Low temperature co-fired ceramics (LTCC) substrate materials, Ca-B-Si-O (CBS), Ca-Al-B-Si-O (CABS), and Ca-Mg-B-Si-O (CMBS), have been prepared, and the biocompatibility of these materials was evaluated. Compared with CBS and CMBS samples, the CABS sample presented the lowest crystallinity and dissolution in the bioleaching experiments. The direct and indirect cell culturing results showed that the CABS sample also possessed the best biocompatibility to the bone mesenchymal stem cells (BMSCs) due to its good bio-stability and surface micro-pore structure. The effects of surface topography and released ions on cytocompatibility were analyzed. These results were expected to offer some guideline information for developing LTCC substrate materials used in the microfluidic biosensors for the future biological and medical application.
引用
收藏
页码：365 / 371
页数：7
相关论文
共 25 条
  • [1] LTCC based bioreactors for cell cultivation
    Bartsch, H.
    Welker, T.
    Welker, K.
    Witte, H.
    Mueller, J.
    [J]. 39TH INTERNATIONAL MICROELECTRONICS AND PACKAGING IMAPS POLAND 2015 CONFERENCE, 2016, 104
  • [2] Microfluidic organs-on-chips
    Bhatia, Sangeeta N.
    Ingber, Donald E.
    [J]. NATURE BIOTECHNOLOGY, 2014, 32 (08) : 760 - 772
  • [3] The effect of biomimetic apatite structure on osteoblast viability, proliferation, and gene expression
    Chou, YF
    Huang, WB
    Dunn, JCY
    Miller, TA
    Wu, BM
    [J]. BIOMATERIALS, 2005, 26 (03) : 285 - 295
  • [4] Monitoring of cell cultures with LTCC microelectrode array
    Ciosek, P.
    Zawadzki, K.
    Lopacinska, J.
    Skolimowski, M.
    Bembnowicz, P.
    Golonka, L. J.
    Brzozka, Z.
    Wroblewski, W.
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2009, 393 (08) : 2029 - 2038
  • [5] In vitro bioactivity of melt-derived glass 46S6 doped with magnesium
    Dietrich, Elodie
    Oudadesse, Hassane
    Lucas-Girot, Anita
    Mami, Mohamed
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2009, 88A (04) : 1087 - 1096
  • [6] Effect of calcium phosphate ceramic substrate geometry on mesenchymal stromal cell organization and osteogenic differentiation
    Edreira, Eva R. Urquia
    Hayrapetyan, Astghik
    Wolke, Joop G. C.
    Croes, Huib J. E.
    Klymov, Alexey
    Jansen, John A.
    van den Beucken, Jeroen J. J. P.
    [J]. BIOFABRICATION, 2016, 8 (02)
  • [7] In vitro evaluation of borate-based bioactive glass scaffolds prepared by a polymer foam replication method
    Fu, Hailuo
    Fu, Qiang
    Zhou, Nai
    Huang, Wenhai
    Rahaman, Mohamed N.
    Wang, Deping
    Liu, Xin
    [J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2009, 29 (07): : 2275 - 2281
  • [8] Hench L.L., 1971, Journal of Biomedical Materials Research Symposium, V36, P117, DOI [DOI 10.1002/JBM.820050611, 10.1002/jbm.820050611]
  • [9] BIOCERAMICS - FROM CONCEPT TO CLINIC
    HENCH, LL
    [J]. JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 1991, 74 (07) : 1487 - 1510
  • [10] A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics
    Hoppe, Alexander
    Gueldal, Nusret S.
    Boccaccini, Aldo R.
    [J]. BIOMATERIALS, 2011, 32 (11) : 2757 - 2774
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