Retrospective study of treatment outcomes after postoperative chemoradiotherapy in Japanese oral squamous cell carcinoma patients with risk factors of recurrence

被引：12

作者：

Hasegawa, Takumi ^{[1
]}

Yanamoto, Souichi ^{[2
]}

Otsuru, Mitsunobu ^{[3
]}

Yamada, Shin-ichi ^{[4
]}

Minamikawa, Tsutomu ^{[1
]}

Shigeta, Takashi ^{[1
]}

Naruse, Tomofumi ^{[2
]}

Suzuki, Takatsugu ^{[3
]}

Sasaki, Masashi ^{[3
]}

Ota, Yoshihide ^{[3
]}

Umeda, Masahiro ^{[2
]}

Komori, Takahide ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Oral & Maxillofacial Surg, Kobe, Hyogo, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Clin Oral Oncol, Nagasaki, Japan

[3] Tokai Univ, Sch Med, Div Surg, Dept Oral & Maxillofacial Surg, Isehara, Kanagawa, Japan

[4] Shinshu Univ, Sch Med, Dept Dent & Oral Surg, Matsumoto, Nagano, Japan

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2017年 / 123卷 / 05期

关键词：

LOCALLY ADVANCED HEAD; NECK-CANCER; CONCURRENT CHEMORADIOTHERAPY; 3-WEEKLY CISPLATIN; RADIATION-THERAPY; PHASE-III; CHEMOTHERAPY; RADIOTHERAPY; FEASIBILITY; DOCETAXEL;

D O I：

10.1016/j.oooo.2016.11.014

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Background. The purpose of this study was to investigate the feasibility of postoperative concomitant chemoradiotherapy (CRT) with cisplatin (CDDP), and compare the prognosis in 3 groups-without postoperative therapy (S-only), with radiotherapy (RT) alone (S+RT), and with CRT (S+CRT) din oral squamous cell carcinoma (OSCC) patients at high risk of recurrence. Methods. Clinicopathologic data and treatment modality were investigated. Endpoints evaluated were locoregional control (LRC), relapse-free survival, overall survival (OS), and type of recurrence. Results. The S+CRT group was associated with a better LRC rate than the S-only (P < .001) and S+RT groups (P = .044). However, there was no significant difference in OS rates between the S+RT and S+CRT groups. Conclusion. The addition of concomitant CDDP to postoperative RT improved LRC. However, there may be no benefit from the addition of concomitant CDDP to postoperative RT for improvement of distant metastasis and OS rates in OSCC patients.

引用

页码：524 / 530

页数：7

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