Alternative solvent-free methodologies in the synthesis of pharmaceutical drugs

被引：0
作者：
Shearouse, William C. [1 ]
Waddell, Daniel C. [1 ]
Mack, James [1 ]
机构：
[1] Univ Cincinnati, Cincinnati, OH 45220 USA
来源：
CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT | 2009年 / 12卷 / 06期
关键词：
Green chemistry; organic synthesis; pharmaceutical; solvent-free; sustainability; ONE-POT SYNTHESIS; GREEN CHEMISTRY; CARBONYL-COMPOUNDS; HIGHLY EFFICIENT; ALDOL REACTION; CATALYZED ESTERIFICATION; MULTICOMPONENT REACTION; SELECTIVE SYNTHESIS; BIOLOGICAL-SYSTEMS; CYCLIC CARBONATES;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Efforts made by chemists to develop more sustainable processes have resulted in a large increase in greener technologies. Because solvents comprise greater than 80% by mass of a pharmaceutical batch process, the incorporation of solvent-free reactions is expected to significantly reduce the quantity of hazardous waste that is generated during these processes. This review highlights a diverse set of solvent-free organic reactions that can be employed in the development of various pharmaceutical drugs.
引用
收藏
页码：772 / 783
页数：12
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