Alternative solvent-free methodologies in the synthesis of pharmaceutical drugs

被引：0
作者：
Shearouse, William C. [1 ]
Waddell, Daniel C. [1 ]
Mack, James [1 ]
机构：
[1] Univ Cincinnati, Cincinnati, OH 45220 USA
来源：
CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT | 2009年 / 12卷 / 06期
关键词：
Green chemistry; organic synthesis; pharmaceutical; solvent-free; sustainability; ONE-POT SYNTHESIS; GREEN CHEMISTRY; CARBONYL-COMPOUNDS; HIGHLY EFFICIENT; ALDOL REACTION; CATALYZED ESTERIFICATION; MULTICOMPONENT REACTION; SELECTIVE SYNTHESIS; BIOLOGICAL-SYSTEMS; CYCLIC CARBONATES;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Efforts made by chemists to develop more sustainable processes have resulted in a large increase in greener technologies. Because solvents comprise greater than 80% by mass of a pharmaceutical batch process, the incorporation of solvent-free reactions is expected to significantly reduce the quantity of hazardous waste that is generated during these processes. This review highlights a diverse set of solvent-free organic reactions that can be employed in the development of various pharmaceutical drugs.
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收藏
页码：772 / 783
页数：12
相关论文
共 120 条
  • [1] *ACS, 2009, ACS GCI PHARM ROUNDT
  • [2] Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation
    Alfonsi, Kim
    Colberg, Juan
    Dunn, Peter J.
    Fevig, Thomas
    Jennings, Sandra
    Johnson, Timothy A.
    Kleine, H. Peter
    Knight, Craig
    Nagy, Mark A.
    Perry, David A.
    Stefaniak, Mark
    [J]. GREEN CHEMISTRY, 2008, 10 (01) : 31 - 36
  • [3] Reductive Amination of carbonyl compounds with NaBH4-H3PW12O40 in THF and under solvent-free conditions
    Alinezhad, Heshmatollah
    Ardestani, Ehsan
    [J]. LETTERS IN ORGANIC CHEMISTRY, 2007, 4 (07) : 473 - 477
  • [4] Solvent-free synthesis of penta-substituted pyrroles: one-pot reaction of amine, alkyl acetoacetate, and furnaryl chloride
    Alizadeh, Abdolah
    Babaki, Mohadese
    Zohreh, Nasrin
    [J]. TETRAHEDRON, 2009, 65 (08) : 1704 - 1707
  • [5] Solvent-Free Synthesis of Hydrazine-Substituted Enaminones via a One-Pot Four-Component Reaction
    Alizadeh, Abdolali
    Babaki, Mohadeseh
    Zohreh, Nasrin
    [J]. SYNTHESIS-STUTTGART, 2008, (20): : 3295 - 3298
  • [6] Prolinamides versus Prolinethioamides as Recyclable Catalysts in the Enantioselective Solvent-Free Inter- and Intramolecular Aldol Reactions
    Almasi, Diana
    Alonso, Diego A.
    Najera, Carmen
    [J]. ADVANCED SYNTHESIS & CATALYSIS, 2008, 350 (16) : 2467 - 2472
  • [7] Anastas P., 1998, GREEN CHEM THEORY PR
  • [8] Unification of reaction metrics for green chemistry II: Evaluation of named organic reactions and application to reaction discovery
    Andraos, J
    [J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2005, 9 (04) : 404 - 431
  • [9] Unification of reaction metrics for green chemistry: Applications to reaction analysis
    Andraos, J
    [J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2005, 9 (02) : 149 - 163
  • [10] Green Analytical Chemistry
    Armenta, S.
    Garrigues, S.
    de la Guardia, M.
    [J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2008, 27 (06) : 497 - 511
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