Antibacterial discovery and development - the failure of success?

被引:192
作者
Fernandes, Prabhavathi [1 ]
机构
[1] Cempra Pharmaceut Inc, Morrisville, NC 27560 USA
关键词
D O I
10.1038/nbt1206-1497
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A combination of approaches and compounds - many of which failed to yield immediate results in the past - will ultimately prove invaluable to the drug industry in the ongoing battle against infectious disease. © 2006 Nature Publishing Group.
引用
收藏
页码:1497 / 1503
页数:7
相关论文
共 79 条
[1]   In vitro activity of OPT-80 against clostridium difcile [J].
Ackermann, G ;
Löffler, B ;
Adler, D ;
Rodloff, AC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (06) :2280-2282
[2]   Resistance to antibiotics: Are we in the post-antibiotic era? [J].
Alanis, AJ .
ARCHIVES OF MEDICAL RESEARCH, 2005, 36 (06) :697-705
[3]  
Andriole V T, 1993, Drugs, V45 Suppl 3, P1
[4]   Recently approved and investigational antibiotics for treatment of severe infections caused by Gram-positive bacteria [J].
Appelbaum, PC ;
Jacobs, MR .
CURRENT OPINION IN MICROBIOLOGY, 2005, 8 (05) :510-517
[5]   The potential impact of structural genomics on tuberculosis drug discovery [J].
Arcus, VL ;
Lott, JS ;
Johnston, JM ;
Baker, EN .
DRUG DISCOVERY TODAY, 2006, 11 (1-2) :28-34
[6]   Antibiotic resistance: The new apocalypse? [J].
Ash, C .
TRENDS IN MICROBIOLOGY, 1996, 4 (10) :371-372
[7]   Adverse drug reactions: implications for the development of fluoroquinolones [J].
Ball, P .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 :21-27
[8]   Inase inhibitors - Surveying the kinome [J].
Brazil, M .
NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (04) :279-279
[9]   TRIMETHOPRIM A SULPHONAMIDE POTENTIATOR [J].
BUSHBY, SRM ;
HITCHING.GH .
BRITISH JOURNAL OF PHARMACOLOGY, 1968, 33 (01) :72-+
[10]   Natural products - The future scaffolds for novel antibiotics? [J].
Butler, MS ;
Buss, AD .
BIOCHEMICAL PHARMACOLOGY, 2006, 71 (07) :919-929