Frequency of Val1016Ile mutation in the voltage-gated sodium channel gene of Aedes aegypti Brazilian populations

被引：74

作者：

Martins, Ademir Jesus ^{[1
,2
]}

Pereira Lima, Jose Bento ^{[1
,2
]}

Peixoto, Alexandre Afranio ^{[3
]}

Valle, Denise ^{[1
,2
]}

机构：

[1] Benfica, Inst Biol Exercito, BR-20911270 Rio De Janeiro, Brazil

[2] Lab Fisiol & Controle Artropodes Vetores, Rio De Janeiro, Brazil

[3] Inst Oswaldo Cruz, Lab Biol Mol Insetos, BR-20001 Rio De Janeiro, Brazil

来源：

TROPICAL MEDICINE & INTERNATIONAL HEALTH | 2009年 / 14卷 / 11期

关键词：

pyrethroid resistance; kdr mutation; sodium channel gene; KNOCKDOWN RESISTANCE KDR; INSECTICIDE RESISTANCE; ANOPHELES-GAMBIAE; ORGANOPHOSPHATES; MECHANISMS; MOSQUITO; STATE;

D O I：

10.1111/j.1365-3156.2009.02378.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

One of the major insect pyrethroid resistance mechanisms affects its target site, the voltage-gated sodium channel (Na-v). In Aedes aegypti, the Val1016Ile substitution of the AaNa(v) gene is associated to resistance in several Latin American countries. Genotyping of susceptible and resistant mosquitoes from seven Brazilian localities detected the 1016Ile mutation in five populations with a higher frequency of this substitution in resistant specimens in all cases. Furthermore, analysis of nine additional field populations revealed that five also presented the 1016Ile mutation. Our data suggest a recent dissemination and involvement of this substitution with pyrethroid resistance in Brazil.

引用

页码：1351 / 1355

页数：5

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