Circadian misalignment in major depressive disorder

被引：189
作者：
Emens, Jonathan [1 ]
Lewy, Alfred [2 ,3 ]
Kinzie, John Mark
Arntz, Diana
Rough, Jennifer
机构：
[1] Oregon Hlth & Sci Univ, Dept Psychiat, Sleep & Mood Disorders Lab, Portland, OR 97239 USA
[2] Oregon Hlth & Sci Univ, Dept Ophthalmol, Portland, OR 97239 USA
[3] Oregon Hlth & Sci Univ, Dept Physiol Pharmacol, Portland, OR 97239 USA
来源：
PSYCHIATRY RESEARCH | 2009年 / 168卷 / 03期
关键词：
Melatonin; Circadian rhythms; Depression; Dim light melatonin onset (DLMO); Phase angle difference (PAD); Sleep; MOOD DISORDERS; SLEEP-WAKE;
D O I：
10.1016/j.psychres.2009.04.009
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
It has been hypothesized that the circadian pacemaker plays a role in major depressive disorder (MDD). We sought to determine if misalignment between the timing of sleep and the pacemaker correlated with symptom severity in MDD. Depression severity correlated with circadian misalignment: the more delayed, the more severe the symptoms. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：259 / 261
页数：3
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