Electrochemical Biosensors for Early Stage Zia Diagnostics

被引：59

作者：

Kaushik, Ajeet ^{[1
]}

Tiwari, Sneham ^{[1
]}

Jayant, Rahul D. ^{[1
]}

Vashist, Arti ^{[1
]}

Nikkhah-Moshaie, Roozbeh ^{[1
]}

Ei-Hage, Nazira ^{[1
]}

Nair, Madhavan ^{[1
]}

机构：

[1] Florida Int Univ, Herbert Wertheim Coll Med, Ctr Personalized Nanomed, Inst Neurolmmune Pharmacol,Dept Immunol, Miami, FL 33199 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2017年 / 35卷 / 04期

基金：

美国国家卫生研究院;

关键词：

ZIKA VIRUS; LABEL-FREE; POINT; TECHNOLOGIES; MANAGEMENT; INFECTION; DISEASE; PCR;

D O I：

10.1016/j.tibtech.2016.10.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Health agencies have declared the recent Zika virus (ZIKV) infection an epidemic and a public health emergency of global concern due to its association with microcephaly and serious neurological disorders. The unavailability of effective drugs, vaccines, and diagnostic tools increases the demand for efficient analytical devices to detect ZIKV infection. However, high costs, longer diagnostic times, and stringent expertise requirements limit the utility of reverse transcriptase-PCR methods for rapid diagnostics. Therefore, developing portable, sensitive, selective, and cost-effective sensing systems to detect ZIKV at picomolar concentrations in biofluids would be a breakthrough in diagnostics and therapeutics. This paper highlights the advancements in developing smart sensing strategies to monitor ZIKV progression, with rapid point-of-care diagnostics as the ultimate aim.

引用

页码：308 / 317

页数：10

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