Signaling pathways of EBV-induced oncogenesis

被引：76

作者：

Luo, Yin ^{[1
]}

Liu, Yitong ^{[1
]}

Wang, Chengkun ^{[1
]}

Gan, Runliang ^{[1
]}

机构：

[1] Univ South China, Sch Med, Canc Res Inst, Chang Sheng Xi Ave 28, Hengyang 421001, Hunan, Peoples R China

来源：

CANCER CELL INTERNATIONAL | 2021年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Epstein‐ barr virus (EBV); Cancer; Signaling pathway;

D O I：

10.1186/s12935-021-01793-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epstein-Barr virus (EBV) is closely associated with multiple human cancers. EBV-associated cancers are mainly lymphomas derived from B cells and T cells (Hodgkin lymphoma, Burkitt lymphoma, NK/T-cell lymphoma, and posttransplant lymphoproliferative disorder (PTLD)) and carcinomas derived from epithelial cells (nasopharyngeal carcinoma and gastric carcinoma). EBV can induce oncogenesis in its host cell by activating various signaling pathways, such as nuclear factor-kappa B (NF-kappa B), phosphoinositide-3-kinase/protein kinase B (PI3K/AKT), Janus kinase/signal transducer and transcription activator (JAK/STAT), mitogen-activated protein kinase (MAPK), transforming growth factor-beta (TGF-beta), and Wnt/beta-catenin, which are regulated by EBV-encoded proteins and noncoding RNA. In this review, we focus on the oncogenic roles of EBV that are mediated through the aforementioned signaling pathways.

引用

页数：11

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