MOV10 as a novel telomerase-associated protein

被引：16

作者：

Nakano, Mariko

Kakiuchi, Yasutaka ^{[1
]}

Shimada, Yukiko

Ohyama, Mika

Ogiwara, Yasuko

Sasaki-Higashiyama, Narie

Yano, Naoko

Ikeda, Fumi

Yamada, Ei ^{[2
]}

Iwamatsu, Akihiro ^{[3
]}

Kobayashi, Kazuo ^{[4
]}

Nishiyama, Kiyoto ^{[5
]}

Ichikawa, Sohsuke ^{[5
]}

Kaji, Kazuhiko ^{[6
]}

Ide, Toshinori ^{[7
]}

Murofushi, Hiromu ^{[8
]}

Murakami-Murofushi, Kimiko

机构：

[1] Ochanomizu Univ, Fac Sci, Dept Biol, Bunkyo Ku, Tokyo 1128610, Japan

[2] AnGes MG Inc, Tokyo 1080014, Japan

[3] Prot Res Network Inc, Yokohama, Kanagawa 2360004, Japan

[4] Kirin Brewery Co Ltd, Prod Dev Sect, Gunma 3700013, Japan

[5] Kikuchi Res Ctr, Chemosero Therapeut Res Inst, Kumamoto 8691298, Japan

[6] Univ Shizuoka, Shizuoka 4228526, Japan

[7] Hiroshima Univ, Grad Sch Biomed Sci, Dept Med Sci, Hiroshima 7398511, Japan

[8] Yamaguchi Univ, Grad Sch Med, Dept Appl Mol Biosci, Yamaguchi 7538511, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 388卷 / 02期

关键词：

MOV10; Telomerase; Telomere DNA; Cancer; Germ cell; CATALYTIC SUBUNIT; HTERT; IDENTIFICATION; CELLS; BINDS;

D O I：

10.1016/j.bbrc.2009.08.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel telomerase-associated protein was isolated from porcine testis. The 115-kDa protein, purified with telomerase activity, was molecular cloned using human cDNA library, and identified as MOV10. The expression levels of both MOV10 mRNA and MOV10 protein in cancer cells were 2-3 times higher than that of the normal cells, and MOV10 mRNA was highly expressed in human testis and ovary. The anti-MOV10 antibody precipitated the telomerase activity from cancer cell extracts, and inhibited the telomerase activity in vitro. Sf9-expressed MOV10 protein bound to G-rich strand of both single-and double-stranded telomere-sequenced DNA, but not to single C-rich strand. ChIP assay showed the binding of MOV10 to telomere region in vivo. These data suggest that MOV10 is involved in the progression of telomerase-catalyzing reaction via the interaction of telomerase protein and telomere DNA. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：328 / 332

页数：5

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