In the present paper, we study simple-direct-injective modules and simple-direct-projective modules over a formal matrix ring K = (R M N S) , where M is an (R, S)-bimodule and N is a (S, R)-bimodule over rings R and S. We determine necessary and sufficient conditions for a K-module to be, respectively, simple-direct-injective or simple-direct-projective. We also give some examples to illustrate and delimit our results.