PROSPECTIVE STUDY OF PERIPHERAL NEUROPATHY IN MACHADO-JOSEPH DISEASE

被引：23

作者：

Franca, Marcondes C., Jr. ^{[2
]}

D'Abreu, Anelyssa ^{[2
]}

Nucci, Anamarli ^{[2
]}

Cendes, Fernando ^{[2
]}

Lopes-Cendes, Iscia ^{[1
]}

机构：

[1] Univ Campinas UNICAMP, Dept Med Genet, BR-13084971 Campinas, SP, Brazil

[2] Univ Campinas UNICAMP, Dept Neurol, BR-13084971 Campinas, SP, Brazil

来源：

MUSCLE & NERVE | 2009年 / 40卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

Machado-Joseph disease; peripheral neuropathy; SCA3; spinocerebellar ataxia type 3; electrophysiologic studies; axonal neuropathy; nerve conduction studies; natural history; DOMINANT CEREBELLAR ATAXIAS; CLINICAL-FEATURES; POLYNEUROPATHY; NERVE; MOTOR; SCORE;

D O I：

10.1002/mus.21396

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Peripheral neuropathy (PN) has long been recognized in Machado-Joseph disease (MJD), but its natural history is an unsettled issue. Therefore, we prospectively assessed 40 with MJD for 13 months with nerve conduction (NC) studies and the revised total neuropathy score (TNSr) to study the progression of PN. There was no significant change in the TNSr score over the follow-up period. In contrast, the average sural sensory nerve action potential (SNAP) amplitude decreased significantly over the same interval from a mean of 13.2 mu V to 9.8 mu V (P < 0.001). There was an inverse correlation between the change in the sural SNAP amplitude and the length of the CAG triplet repeat expansion (r = 0.574, P < 0.001). The reduction in the mean sural SNAP amplitude also correlated with progression of ataxia. This indicates that PN progresses faster in individuals with larger (CAG)(n) expansions, and nerve conduction studies may be useful to study disease progression in MJD. Muscle Nerve 40:1012-1018, 2009

引用

页码：1012 / 1018

页数：7

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