Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

被引：99

作者：

Creaven, Bernadette S. ^{[1
,2
]}

Devereux, Michael ^{[3
]}

Karcz, Dariusz ^{[1
,2
]}

Kellett, Andrew ^{[3
]}

McCann, Malachy ^{[4
]}

Noble, Andy ^{[5
]}

Walsh, Maureen ^{[1
,2
]}

机构：

[1] Inst Technol Tallaght, Dept Sci, Dublin 24, Ireland

[2] Inst Technol Tallaght, Ctr Appl Sci & Hlth, Dublin 24, Ireland

[3] Dublin Inst Technol, Focas Inst, Inorgan Pharmaceut & Biomimet Res Grp, Dublin 2, Ireland

[4] Natl Univ Ireland, Dept Chem, Maynooth, Kildare, Ireland

[5] Univ Otago, Dept Chem, Dunedin, New Zealand

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2009年 / 103卷 / 09期

关键词：

Coumarin; Copper; Metal complexes; X-ray crystal structures; Antifungal; RAY CRYSTAL-STRUCTURES; ANTIFUNGAL DRUG-RESISTANCE; IN-VITRO ANTIBACTERIAL; ANTIMICROBIAL ACTIVITY; X-RAY; BIOLOGICAL-ACTIVITY; METAL-COMPLEXES; CYTOTOXIC ACTIVITIES; MAGNETIC-PROPERTIES; FUNGAL-INFECTIONS;

D O I：

10.1016/j.jinorgbio.2009.05.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1196 / 1203

页数：8

共 71 条

[41] STUDY OF THE RELATION BETWEEN THE STRUCTURAL DATA AND MAGNETIC INTERACTION IN OXO-BRIDGED BINUCLEAR COPPER(II) COMPOUNDS [J].

MELNIK, M .

COORDINATION CHEMISTRY REVIEWS, 1982, 42 (02) :259-293

[42] Synthesis and antibacterial activity of some Schiff base complexes [J].

Nair, R. ;

Shah, A. ;

Baluja, S. ;

Chanda, S. .

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2006, 71 (07) :733-744

[43]

*NCCL, 1979, M27P NCCL

[44] Novel coumarin derivatives with expected biological activity [J].

Nofal, ZM ;

El-Zahar, MI ;

El-Karim, SSA .

MOLECULES, 2000, 5 (02) :99-113

[45] Antimicrobial activity of some coumarin containing herbal plants growing in Finland [J].

Ojala, T ;

Remes, S ;

Haansuu, P ;

Vuorela, H ;

Hiltunen, R ;

Haahtela, K ;

Vuorela, P .

JOURNAL OF ETHNOPHARMACOLOGY, 2000, 73 (1-2) :299-305

[46] X-ray, spectral and biological (antimicrobial and superoxide dismutase) studies of oxalato bridged CuII-NiII and CuII-ZnII complexes with pentamethyldiethylenetriamine as capping ligand [J].

Patel, RN ;

Singh, N ;

Shukla, KK ;

Chauhan, UK ;

Chakraborty, S ;

Niclós-Gutiérrez, J ;

Castiñeiras, A .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2004, 98 (02) :231-237

[47] Transition metal complexes with Schiff-base ligands: 4-aminoantipyrine based derivatives - a review [J].

Raman, N. ;

Johnson Raja, S. ;

Sakthivel, A. .

JOURNAL OF COORDINATION CHEMISTRY, 2009, 62 (05) :691-709

[48]

Randhawa Muhammad Akram, 2006, Nihon Ishinkin Gakkai Zasshi, V47, P313, DOI 10.3314/jjmm.47.313

[49] In-vitro antibacterial, antifungal and cytotoxic activities of some coumarins and their metal complexes [J].

Rehman, SU ;

Chohan, ZH ;

Gulnaz, F ;

Supuran, CT .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2005, 20 (04) :333-340

[50] Cytotoxic effects of mammea type coumarins from Calophyllum brasiliense [J].

Reyes-Chilpa, R ;

Estrada-Muñiz, E ;

Apan, TR ;

Amekraz, B ;

Aumelas, A ;

Jankowski, CK ;

Vázquez-Torres, M .

LIFE SCIENCES, 2004, 75 (13) :1635-1647

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