Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

被引：96
作者：
Creaven, Bernadette S. [1 ,2 ]
Devereux, Michael [3 ]
Karcz, Dariusz [1 ,2 ]
Kellett, Andrew [3 ]
McCann, Malachy [4 ]
Noble, Andy [5 ]
Walsh, Maureen [1 ,2 ]
机构：
[1] Inst Technol Tallaght, Dept Sci, Dublin 24, Ireland
[2] Inst Technol Tallaght, Ctr Appl Sci & Hlth, Dublin 24, Ireland
[3] Dublin Inst Technol, Focas Inst, Inorgan Pharmaceut & Biomimet Res Grp, Dublin 2, Ireland
[4] Natl Univ Ireland, Dept Chem, Maynooth, Kildare, Ireland
[5] Univ Otago, Dept Chem, Dunedin, New Zealand
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2009年 / 103卷 / 09期
关键词：
Coumarin; Copper; Metal complexes; X-ray crystal structures; Antifungal; RAY CRYSTAL-STRUCTURES; ANTIFUNGAL DRUG-RESISTANCE; IN-VITRO ANTIBACTERIAL; ANTIMICROBIAL ACTIVITY; X-RAY; BIOLOGICAL-ACTIVITY; METAL-COMPLEXES; CYTOTOXIC ACTIVITIES; MAGNETIC-PROPERTIES; FUNGAL-INFECTIONS;
D O I：
10.1016/j.jinorgbio.2009.05.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B. (C) 2009 Elsevier Inc. All rights reserved.
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收藏
页码：1196 / 1203
页数：8
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