Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

被引：99

作者：

Creaven, Bernadette S. ^{[1
,2
]}

Devereux, Michael ^{[3
]}

Karcz, Dariusz ^{[1
,2
]}

Kellett, Andrew ^{[3
]}

McCann, Malachy ^{[4
]}

Noble, Andy ^{[5
]}

Walsh, Maureen ^{[1
,2
]}

机构：

[1] Inst Technol Tallaght, Dept Sci, Dublin 24, Ireland

[2] Inst Technol Tallaght, Ctr Appl Sci & Hlth, Dublin 24, Ireland

[3] Dublin Inst Technol, Focas Inst, Inorgan Pharmaceut & Biomimet Res Grp, Dublin 2, Ireland

[4] Natl Univ Ireland, Dept Chem, Maynooth, Kildare, Ireland

[5] Univ Otago, Dept Chem, Dunedin, New Zealand

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2009年 / 103卷 / 09期

关键词：

Coumarin; Copper; Metal complexes; X-ray crystal structures; Antifungal; RAY CRYSTAL-STRUCTURES; ANTIFUNGAL DRUG-RESISTANCE; IN-VITRO ANTIBACTERIAL; ANTIMICROBIAL ACTIVITY; X-RAY; BIOLOGICAL-ACTIVITY; METAL-COMPLEXES; CYTOTOXIC ACTIVITIES; MAGNETIC-PROPERTIES; FUNGAL-INFECTIONS;

D O I：

10.1016/j.jinorgbio.2009.05.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1196 / 1203

页数：8

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