PROTEINURIA Usefulness of RAS inhibition depends on baseline albuminuria

被引：7

作者：

Ito, Sadayoshi ^{[1
]}

机构：

[1] Tohoku Univ, Sch Med, Dept Med, Div Nephrol Endocrinol & Vasc Med,Aoba Ku, Sendai, Miyagi 9808574, Japan

来源：

NATURE REVIEWS NEPHROLOGY | 2010年 / 6卷 / 01期

关键词：

DIABETIC-NEPHROPATHY; CONTROLLED TRIAL; RENAL OUTCOMES; LOSARTAN; RAMIPRIL; TARGET; RISK;

D O I：

10.1038/nrneph.2009.203

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In patients at low risk of renal disease and with low levels of albuminuria, administration of renin-angiotensin system inhibitors does not seem to offer renal benefits and might cause adverse renal effects. In these patients, renin-angiotensin system inhibition should be implemented judiciously, with doses titrated to individual needs and with careful monitoring of kidney function.

引用

页码：10 / 11

页数：2

共 10 条

[1] Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis - A randomized controlled trial [J].

Agodoa, LY ;

Appel, L ;

Bakris, GL ;

Beck, G ;

Bourgoignie, J ;

Briggs, JP ;

Charleston, J ;

Cheek, D ;

Cleveland, W ;

Douglas, JG ;

Douglas, M ;

Dowie, D ;

Faulkner, M ;

Gabriel, A ;

Gassman, J ;

Greene, T ;

Hall, Y ;

Hebert, L ;

Hiremath, L ;

Jamerson, K ;

Johnson, CJ ;

Kopple, J ;

Kusek, J ;

Lash, J ;

Lea, J ;

Lewis, JB ;

Lipkowitz, M ;

Massry, S ;

Middleton, J ;

Miller, ER ;

Norris, K ;

O'Connor, D ;

Ojo, A ;

Phillips, RA ;

Pogue, V ;

Rahman, M ;

Randall, OS ;

Rostand, S ;

Schulman, G ;

Smith, W ;

Thornley-Brown, D ;

Tisher, CC ;

Toto, RD ;

Wright, JT ;

Xu, SC .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (21) :2719-2728

[2] Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy [J].

Brenner, BM ;

Cooper, ME ;

de Zeeuw, D ;

Keane, WF ;

Mitch, WE ;

Parving, HH ;

Remuzzi, G ;

Snapinn, SM ;

Zhang, ZX ;

Shahinfar, S .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (12) :861-869

[3] Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy [J].

de Zeeuw, D ;

Remuzzi, G ;

Parving, HH ;

Keane, WF ;

Zhang, ZX ;

Shahinfar, S ;

Snapinn, S ;

Cooper, ME ;

Mitch, WE ;

Brenner, BM .

CIRCULATION, 2004, 110 (08) :921-927

[4] Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: Lessons from RENAAL [J].

de Zeeuw, D ;

Remuzzi, G ;

Parving, HH ;

Keane, WF ;

Zhang, ZX ;

Shahinfar, S ;

Snapinn, S ;

Cooper, MF ;

Mitch, WE ;

Brenner, BM .

KIDNEY INTERNATIONAL, 2004, 65 (06) :2309-2320

[5] Reduction in albuminuria translates to reduction in cardiovascular events in hypertensive patients -: Losartan intervention for endpoint reduction in hypertension study [J].

Ibsen, H ;

Olsen, MH ;

Wachtell, K ;

Borch-Johnsen, K ;

Lindholm, LH ;

Mogensen, CE ;

Dahlöf, B ;

Devereux, RB ;

de Faire, U ;

Fyhrquist, F ;

Julius, S ;

Kjeldsen, SE ;

Lederballe-Pedersen, O ;

Nieminen, MS ;

Omvik, P ;

Oparil, S ;

Wan, Y .

HYPERTENSION, 2005, 45 (02) :198-202

[6] Strain vessel hypothesis: a viewpoint for linkage of albuminuria and cerebro-cardiovascular risk [J].

Ito, Sadayoshi ;

Nagasawa, Tasuku ;

Abe, Michiaki ;

Mori, Takefumi .

HYPERTENSION RESEARCH, 2009, 32 (02) :115-121

[7] Angiotensin-converting enzyme inhibitors and progression of nondiabetic renal disease - A meta-analysis of patient-level data [J].

Jafar, TH ;

Schmid, CH ;

Landa, M ;

Giatras, I ;

Toto, R ;

Remuzzi, G ;

Maschio, G ;

Brenner, BM ;

Kamper, A ;

Zucchelli, P ;

Becker, G ;

Himmelmann, A ;

Bannister, K ;

Landais, P ;

Shahinfar, S ;

de Jong, PE ;

de Zeeuw, D ;

Lau, J ;

Levey, AS .

ANNALS OF INTERNAL MEDICINE, 2001, 135 (02) :73-87

[8] THE EFFECT OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITION ON DIABETIC NEPHROPATHY [J].

LEWIS, EJ ;

HUNSICKER, LG ;

BAIN, RP ;

ROHDE, RD .

NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (20) :1456-1462

[9] Effect of Telmisartan on Renal Outcomes A Randomized Trial [J].

Mann, Johannes F. E. ;

Schmieder, Roland E. ;

Dyal, Leanne ;

McQueen, Matthew J. ;

Schumacher, Helmut ;

Pogue, Janice ;

Wang, Xingyu ;

Probstfield, Jeffrey L. ;

Avezum, Alvaro ;

Cardona-Munoz, Ernesto ;

Dagenais, Gilles R. ;

Diaz, Rafael ;

Fodor, George ;

Maillon, Jean M. ;

Ryden, Lars ;

Yu, Cheuk M. ;

Teo, Koon K. ;

Yusuf, Salim .

ANNALS OF INTERNAL MEDICINE, 2009, 151 (01) :1-U15

[10]

1997, LANCET, V349, P1857

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