Arc1p: Anchoring, routing, coordinating

被引：17

作者：

Frechin, Mathieu ^{[1
]}

Kern, Daniel ^{[1
]}

Martin, Robert Pierre ^{[2
]}

Becker, Hubert Dominique ^{[1
]}

Senger, Bruno ^{[1
]}

机构：

[1] Univ Strasbourg, CNRS, Inst Biol Mol & Cellulaire, UPR Architecture & React ARN 9002, F-67084 Strasbourg, France

[2] Univ Strasbourg, CNRS, Dept Mol & Cellular Genet, UMR Genet Mol Genom Microbiol 7156, F-67084 Strasbourg, France

来源：

FEBS LETTERS | 2010年 / 584卷 / 02期

关键词：

Dual localization; Aminoacylation; tRNA; Mitochondria; Metabolism; Saccharomyces cerevisiae; TRANSFER-RNA SYNTHETASES; SACCHAROMYCES-CEREVISIAE; BINDING PROTEIN; MAMMALIAN TRANSLATION; COMPLEX-FORMATION; EXPORT MACHINERY; YEAST; IDENTIFICATION; AMINOACYLATION; GLN-TRNA(GLN);

D O I：

10.1016/j.febslet.2009.11.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accurate synthesis of aminoacyl-tRNAs (aa-tRNA) by aminoacyl-tRNA synthetases (aaRS) is an absolute requirement for errorless decoding of the genetic code and is studied since more than four decades. In all three kingdoms of life aaRSs are capable of assembling into multi-enzymatic complexes that are held together by auxiliary non-enzymatic factors, but the role of such macromolecular assemblies is still poorly understood. In the yeast Saccharomyces cerevisiae, Arc1p holds cytosolic methionyl-tRNA synthetase (cMRS) and glutamyl-tRNA synthetase (cERS) together and plays an important role in fine tuning several cellular processes like aminoacylation, translation and carbon source adaptation. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：427 / 433

页数：7

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