Regenerative Medicine and the Hope for a Cure

被引:0
作者
Lehmann, Mareike [1 ]
Koenigshoff, Melanie [1 ,2 ]
机构
[1] German Ctr Lung Res DZL, Helmholtz Zentrum Munchen, Res Unit Lung Repair & Regenerat, Max Lebsche Pl 31, D-81377 Munich, Germany
[2] Univ Pittsburgh, Dept Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA USA
关键词
ILD; IPF; Regeneration; Translation; Aging; Cellular senescence; Developmental pathways; IDIOPATHIC PULMONARY-FIBROSIS; CELLULAR SENESCENCE; LUNG DEVELOPMENT; STEM-CELLS; ALVEOLAR PROGENITOR; AGING LUNG; WNT; MECHANISMS; REPAIR; TGF;
D O I
10.1016/j.ccm.2021.03.012
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
[No abstract available]
引用
收藏
页码:365 / 373
页数:9
相关论文
共 92 条
[1]   Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis [J].
Adams, Taylor S. ;
Schupp, Jonas C. ;
Poli, Sergio ;
Ayaub, Ehab A. ;
Neumark, Nir ;
Ahangari, Farida ;
Chu, Sarah G. ;
Raby, Benjamin A. ;
DeTullis, Giuseppe ;
Januszyk, Michael ;
Duan, Qiaonan ;
Arnett, Heather A. ;
Siddiqui, Asim ;
Washko, George R. ;
Homer, Robert ;
Yan, Xiting ;
Rosas, Ivan O. ;
Kaminski, Naftali .
SCIENCE ADVANCES, 2020, 6 (28)
[2]  
Ahmad, 2017, LUNG EPITHELIAL BIOL, P91, DOI DOI 10.1016/B978-0-12-803809-3.00006-3
[3]   Applications and Approaches for Three-Dimensional Precision-Cut Lung Slices Disease Modeling and Drug Discovery [J].
Alsafadi, Hani N. ;
Uhl, Franziska E. ;
Pineda, Ricardo H. ;
Bailey, Kolene E. ;
Rojas, Mauricio ;
Wagner, Darcy E. ;
Koenigshoff, Melanie .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2020, 62 (06) :681-691
[4]   An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices [J].
Alsafadi, Hani N. ;
Staab-Weijnitz, Claudia A. ;
Lehmann, Mareike ;
Lindner, Michael ;
Peschel, Britta ;
Koenigshoff, Melanie ;
Wagner, Darcy E. .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2017, 312 (06) :L896-L902
[5]   IPF lung fibroblasts have a senescent phenotype [J].
Alvarez, Diana ;
Cardenes, Nayra ;
Sellares, Jacobo ;
Bueno, Marta ;
Corey, Catherine ;
Hanumanthu, Vidya Sagar ;
Peng, Yating ;
D'Cunha, Hannah ;
Sembrat, John ;
Nouraie, Mehdi ;
Shanker, Swaroop ;
Caufield, Chandler ;
Shiva, Sruti ;
Armanios, Mary ;
Mora, Ana L. ;
Rojas, Mauricio .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2017, 313 (06) :L1164-L1173
[6]   An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics [J].
Angelidis, Ilias ;
Simon, Lukas M. ;
Fernandez, Isis E. ;
Strunz, Maximilian ;
Mayr, Christoph H. ;
Greiffo, Flavia R. ;
Tsitsiridis, George ;
Ansari, Meshal ;
Graf, Elisabeth ;
Strom, Tim-Matthias ;
Nagendran, Monica ;
Desai, Tushar ;
Eickelberg, Oliver ;
Mann, Matthias ;
Theis, Fabian J. ;
Schiller, Herbert B. .
NATURE COMMUNICATIONS, 2019, 10 (1)
[7]   The Role of Telomerase and Telomeres in Interstitial Lung Diseases: From Molecules to Clinical Implications [J].
Arish, Nissim ;
Petukhov, Dmytro ;
Wallach-Dayan, Shulamit B. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (12)
[8]   Lung organoids: current uses and future promise [J].
Barkauskas, Christina E. ;
Chung, Mei-I ;
Fioret, Bryan ;
Gao, Xia ;
Katsura, Hiroaki ;
Hogan, Brigid L. M. .
DEVELOPMENT, 2017, 144 (06) :986-997
[9]   Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases [J].
Barnes, Peter J. ;
Baker, Jonathan ;
Donnelly, Louise E. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 200 (05) :556-564
[10]   The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future [J].
Basil, Maria C. ;
Katzen, Jeremy ;
Engler, Anna E. ;
Guo, Minzhe ;
Herriges, Michael J. ;
Kathiriya, Jaymin J. ;
Windmueller, Rebecca ;
Ysasi, Alexandra B. ;
Zacharias, William J. ;
Chapman, Hal A. ;
Kotton, Darrell N. ;
Rock, Jason R. ;
Snoeck, Hans-Willem ;
Vunjak-Novakovic, Gordana ;
Whitsett, Jeffrey A. ;
Morrisey, Edward E. .
CELL STEM CELL, 2020, 26 (04) :482-502