Association Between Interleukin-6 and Head and Neck Squamous Cell Carcinoma: A Systematic Review

被引：23

作者：

Uz, Uzdan ^{[1
]}

Eskiizmir, Gorkem ^{[2
]}

机构：

[1] Univ Hlth Sci, Izmir Bozyaka Training & Res Hosp, Dept Otolaryngol Head & Neck Surg, Izmir, Turkey

[2] Manisa Celal Bayar Univ, Dept Otolaryngol Head & Neck Surg, Manisa, Turkey

来源：

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY | 2021年 / 14卷 / 01期

关键词：

Interleukin; 6; Survival; Carcinogenesis; Inflammation; Head and Neck Neoplasms; NF-KAPPA-B; CANCER CACHEXIA UPDATE; NECROSIS-FACTOR-ALPHA; ORAL-CANCER; SALIVARY INTERLEUKIN-6; CYTOKINE SECRETION; SERUM-LEVELS; TNF-ALPHA; IL-6; BIOMARKERS;

D O I：

10.21053/ceo.2019.00906

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Interleukin-6 (IL-6) is a proinflammatory cytokine which plays an important role in several regulatory mechanisms of cancer. Moreover, experimental and clinical studies have reported that IL-6 targeted therapies might provide significant benefits for cancer treatment. The purpose of this systematic review is to evaluate IL-6 activity in patients with head and neck squamous cell carcinoma (HNSCC"). A systematic review of the association between serum, saliva and tumor IL-6 and HNSCC was developed on PubMed/Medline in the publication range from January 1995 to January 2019. Our literature analysis demonstrated that overexpression and elevated serum and/or saliva 1L-6 concentrations in patients with HNSCC are related to poor survival and oncological outcomes. Although there is a correlation between IL-6 concentrations and tumorigenicity, it is noteworthy that IL-6 targeted therapies are generally performed in vitro and in experimental studies.Therefore, prospective, randomized clinical trials are required that focus on IL-6 targeted therapies for the treatment of HNSCC.

引用

页码：50 / 60

页数：11

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