Preformulation investigation of the novel proton pump inhibitor lansoprazole

被引：27
作者：
Kristl, A
Vrecer, F
机构：
[1] Univ Ljubljana, Fac Pharm, Ljubljana 1000, Slovenia
[2] KRKA DD, Novo Mesto, Div Res & Dev, Novo Mesto 8501, Slovenia
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2000年 / 26卷 / 07期
关键词：
lansoprazole; log P; physicochemical properties; pK(a);
D O I：
10.1081/DDC-100101299
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some technologically important physicochemical properties of lansoprazole were investigated. This compound is very unstable, especially in aqueous solutions with low pH. It has one acidic and two basic dissociation constants. lansoprazole has relatively high solubility in solutions with high pH an dis well partitioned from aqueous to n-octanol phase. Under conditions examined in this study, lansoprazole was not hydroscopic and did not decompose at higher relative humidities.
引用
收藏
页码：781 / 783
页数：3
相关论文
共 4 条
[1]   THE STRENGTH OF HETEROCYCLIC BASES [J].
ALBERT, A ;
GOLDACRE, R ;
PHILLIPS, J .
JOURNAL OF THE CHEMICAL SOCIETY, 1948, (DEC) :2240-2249
[2]   LANSOPRAZOLE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES AND ITS THERAPEUTIC EFFICACY IN ACID-RELATED DISORDERS [J].
BARRADELL, LB ;
FAULDS, D ;
MCTAVISH, D .
DRUGS, 1992, 44 (02) :225-250
[3]   STABILIZATION OF A NEW ANTIULCER DRUG (LANSOPRAZOLE) IN THE SOLID DOSAGE FORMS [J].
TABATA, T ;
MAKINO, T ;
KASHIHARA, T ;
HIRAI, S ;
KITAMORI, N ;
TOGUCHI, H .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1992, 18 (13) :1437-1447
[4]   MANUFACTURING METHOD OF STABLE ENTERIC GRANULES OF A NEW ANTIULCER DRUG (LANSOPRAZOLE) [J].
TABATA, T ;
MAKINO, T ;
KIKUTA, J ;
HIRAI, S ;
KITAMORI, N .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1994, 20 (09) :1661-1672
1