Dose-response association between vitamin D deficiency and atopic dermatitis in children, and effect modification by gender: a case-control study

被引:13
|
作者
Mohamed, Amal Ahmed [1 ]
Ahmed, Eman Mohamed Salah [2 ]
Farag, Youssef M. K. [3 ,4 ]
Bedair, Nermeen Ibrahim [2 ]
Nassar, Nourelhuda Ahmed [5 ]
Ghanem, Ayat Ibrahim Mohamed [6 ]
机构
[1] Natl Hepatol & Trop Med Res Inst, Biochem Dept, Cairo, Egypt
[2] Helwan Univ, Dept Dermatol Androl Sexual Med & STDs, Fac Med, Cairo, Egypt
[3] Johns Hopkins Bloomberg Sch Publ Hlth, Welch Ctr Prevent Epidemiol & Clin Res & Clin Res, Baltimore, MD USA
[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[5] Elsahel Teaching Hosp, Clin Pathol Dept, Cairo, Egypt
[6] Natl Inst Diabet & Endocrinol, Clin Pathol Dept, Cairo, Egypt
关键词
Vitamin D deficiency; 25-hydroxyvitamin D; 25(OH)D; atopic dermatitis; children; gender; effect modification; dose-response; case-control study; 25-HYDROXYVITAMIN D LEVELS; RECEPTOR GENE POLYMORPHISMS; SKIN BARRIER; SEVERITY; DISEASE; INNATE; LEVEL;
D O I
10.1080/09546634.2019.1643447
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Vitamin D is a regulatory factor for immunity and skin barrier functions. It is hypothesized to be linked to atopic dermatitis (AD) which is characterized by interaction between epidermal barrier dysfunction and dysregulation of skin immune functions. Methods: One hundred AD patients and one hundred and one normal controls were collected from outpatient clinic based on their clinical condition, both had measurement of 25-hydroxyvitamin D [25(OH)D]. We assessed the relationship between 25(OH)D deficiency and AD prevalence using adjusted Poisson regression model. Results: Serum 25(OH)D levels were significantly lower in cases than controls (mean 35.1 versus 22.6 ng/mL, p < .001). The unadjusted prevalence ratios (PRs) (95% CI) for AD for comparing participants with intermediate and deficient vitamin D levels to those with optimal levels were 3.11 (1.91, 5.06) and 4.77 (2.99, 7.60), respectively. The association did not materially change after adjusting for potential confounders. In the fully adjusted analysis stratified by gender, PRs for AD for comparing male participants with intermediate and deficient vitamin D levels to those with optimal levels were 3.38 (1.21, 9.40) and 5.20 (1.91, 14.13), respectively, whereas in the female participants were 1.32 (0.96, 1.83) and 1.49 (1.04, 2.14), respectively (p-interaction <.001). Conclusion: In this case-control study in children, we found a statistically significant dose-response association between vitamin D deficiency and AD. We also observed a statistically significant effect modification of this association by gender. Further research is recommended to study this association longitudinally, and to examine whether treating vitamin D deficiency may potentially improve AD.
引用
收藏
页码:174 / 179
页数:6
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