Clinical evaluation of free PSA total PSA (prostate-specific antigen) ratio in the diagnosis of prostate cancer

被引：14
|
作者：
Filella, X [1 ]
Alcover, J [1 ]
Molina, R [1 ]
Rodriguez, A [1 ]
Carretero, P [1 ]
Ballesta, AM [1 ]
机构：
[1] HOSP CLIN BARCELONA,DEPT UROL,BARCELONA 08036,SPAIN
来源：
EUROPEAN JOURNAL OF CANCER | 1997年 / 33卷 / 08期
关键词：
PSA; free PSA; prostate cancer;
D O I：
10.1016/S0959-8049(97)00081-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The objective of this study was to evaluate the utility of the free/total prostate-specific antigen (PSA) ratio (per cent free PSA) in the diagnosis of prostate cancer. Serum total PSA and free PSA concentrations were measured in 156 patients with benign prostate hyperplasia (BPH) and 74 patients with prostate cancer using Hybritech Tandem immunoradiometric assays. Patients with prostate cancer had a significantly lower free/total PSA ratio than patients with BPH, although the distributions across study groups overlapped. In patients with a total PSA level between 4 mu g/l and 25 mu g/l, free/total PSA demonstrated better diagnostic utility than total PSA alone. (C) 1997 Published by Elsevier Science Ltd.
引用
收藏
页码：1226 / 1229
页数：4
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