Synthesis of an Unlocked Nucleic Acid Terpyridine Monomer and Binding of Divalent Metal Ion in Nucleic Acid Duplexes

被引:16
|
作者
Karlsen, Kasper K. [1 ]
Jensen, Troels B. [1 ]
Wengel, Jesper [1 ]
机构
[1] Univ So Denmark, Dept Chem & Phys, Nucle Acid Ctr, Odense, Denmark
来源
JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 22期
基金
新加坡国家研究基金会;
关键词
DNA; MODULATION; 2'-AMINO-LNA; STABILITY;
D O I
10.1021/jo9019978
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Herein we present the synthesis and thermal stability studies of modified oligonucleotides containing an unlocked nucleic acid (UNA) terpyridine monomer. Incorporation of this monomer into both strands of a DNA duplex allowed reversible thermal stability modulation upon addition or withdrawal of divalent metal ions. A likely explanation of this phenomenon is interstrand complexation between two terpyridine units and a metal ion. This system could be useful in the development of nanoscale devices based on DNA hybridization.
引用
收藏
页码:8838 / 8841
页数:4
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