Synthesis of an Unlocked Nucleic Acid Terpyridine Monomer and Binding of Divalent Metal Ion in Nucleic Acid Duplexes

被引：16
|
作者：
Karlsen, Kasper K. [1 ]
Jensen, Troels B. [1 ]
Wengel, Jesper [1 ]
机构：
[1] Univ So Denmark, Dept Chem & Phys, Nucle Acid Ctr, Odense, Denmark
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 22期
基金：
新加坡国家研究基金会;
关键词：
DNA; MODULATION; 2'-AMINO-LNA; STABILITY;
D O I：
10.1021/jo9019978
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we present the synthesis and thermal stability studies of modified oligonucleotides containing an unlocked nucleic acid (UNA) terpyridine monomer. Incorporation of this monomer into both strands of a DNA duplex allowed reversible thermal stability modulation upon addition or withdrawal of divalent metal ions. A likely explanation of this phenomenon is interstrand complexation between two terpyridine units and a metal ion. This system could be useful in the development of nanoscale devices based on DNA hybridization.
引用
收藏
页码：8838 / 8841
页数：4
相关论文
共 50 条
  • [31] Incorporation of porphyrin acetylides into duplexes of the simplified nucleic acid GNA
    Zhou, Hui
    Johnson, Andrew T.
    Wiest, Olaf
    Zhang, Lilu
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 9 (08) : 2840 - 2849
  • [32] Isolation of nucleic acid binding proteins - An approach for isolation of cell surface, nucleic acid binding proteins
    Chelobanov, BP
    Laktionov, PP
    Kharkova, MV
    Rykova, EY
    Vlassov, VV
    CIRCULATING NUCLEIC ACIDS IN PLASMA/SERUM III AND SERUM PROTEOMICS, 2004, 1022 : 239 - 243
  • [33] Roles of electrostricted and structural hydration in the stability of nucleic acid duplexes
    Marky, Luis A.
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 210A - 210A
  • [34] Nucleic acid duplexes incorporating a dissociable covalent base pair
    Gao, K
    Orgel, LE
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) : 14837 - 14842
  • [35] An approach to predicting the stabilities of peptide nucleic acid:DNA duplexes
    Griffin, TJ
    Smith, LM
    ANALYTICAL BIOCHEMISTRY, 1998, 260 (01) : 56 - 63
  • [36] The structural plasticity of nucleic acid duplexes revealed by WAXS and MD
    He, Weiwei
    Chen, Yen-Lin
    Pollack, Lois
    Kirmizialtin, Serdal
    SCIENCE ADVANCES, 2021, 7 (17)
  • [37] Incorporation of porphyrin acetylides into duplexes of the simplified nucleic acid GNA
    Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße, D-35032 Marburg, Germany
    不详
    Org. Biomol. Chem., 8 (2840-2849):
  • [38] Synthesis of fluorobenzene and benzimidazole nucleic-acid analogues and their influence on stability of RNA duplexes
    Parsch, J
    Engels, JW
    HELVETICA CHIMICA ACTA, 2000, 83 (08) : 1791 - 1808
  • [39] Nucleic acid binding properties of the nucleic acid chaperone domain of hepatitis delta antigen
    Wang, CC
    Chang, TC
    Lin, CW
    Tsui, HL
    Chu, PBC
    Chen, BS
    Huang, ZS
    Wu, HN
    NUCLEIC ACIDS RESEARCH, 2003, 31 (22) : 6481 - 6492
  • [40] Synthesis of Nucleic Acid Mimics and Their Application in Nucleic Acid-based Medicine
    Kitamura, Yoshiaki
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2016, 136 (11): : 1491 - 1499
12345