Synthesis of an Unlocked Nucleic Acid Terpyridine Monomer and Binding of Divalent Metal Ion in Nucleic Acid Duplexes

被引：16

作者：

Karlsen, Kasper K. ^{[1
]}

Jensen, Troels B. ^{[1
]}

Wengel, Jesper ^{[1
]}

机构：

[1] Univ So Denmark, Dept Chem & Phys, Nucle Acid Ctr, Odense, Denmark

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 22期

基金：

新加坡国家研究基金会;

关键词：

DNA; MODULATION; 2'-AMINO-LNA; STABILITY;

D O I：

10.1021/jo9019978

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we present the synthesis and thermal stability studies of modified oligonucleotides containing an unlocked nucleic acid (UNA) terpyridine monomer. Incorporation of this monomer into both strands of a DNA duplex allowed reversible thermal stability modulation upon addition or withdrawal of divalent metal ions. A likely explanation of this phenomenon is interstrand complexation between two terpyridine units and a metal ion. This system could be useful in the development of nanoscale devices based on DNA hybridization.

引用

页码：8838 / 8841

页数：4

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