Cellular mechanisms of epithelial stem cell self-renewal and differentiation during homeostasis and repair

被引：26
作者：
Das, Diya [1 ,2 ,5 ]
Fletcher, Russell B. [1 ,6 ]
Ngai, John [1 ,3 ,4 ]
机构：
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Berkeley Inst Data Sci, Berkeley, CA 94720 USA
[3] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
[4] Univ Calif Berkeley, QB3 Funct Genom Lab, Berkeley, CA 94720 USA
[5] Genentech Inc, Dev Sci Informat, 1 DNA Way,Mailstop 98, San Francisco, CA 94080 USA
[6] Surrozen Inc, Discovery Biol Grp, 171 Oyster Point Blvd,Suite 400, San Francisco, CA 94080 USA
来源：
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY | 2020年 / 9卷 / 01期
基金：
美国国家卫生研究院;
关键词：
adult stem cell; tissue homeostasis; tissue repair; epithelia; REGULATORY T-CELLS; HORIZONTAL BASAL-CELLS; HAIR-FOLLICLE; INTESTINAL REGENERATION; PROGENITOR CELLS; SECRETORY PRECURSORS; NEURONAL PROGENITORS; WNT/BETA-CATENIN; LUNG DEVELOPMENT; IN-VIVO;
D O I：
10.1002/wdev.361
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Epithelia in adult mammals exhibit remarkable regenerative capacities owing to the presence of adult stem cells, which self-renew and differentiate to replace cells lost to normal turnover or injury. The mechanisms supporting tissue homeostasis and injury-induced repair often differ from each other as well as from those used in embryonic development. Recent studies have also highlighted the phenomenon of cellular plasticity in adult tissues, in which differentiated cells can change fate and even give rise to new stem cell populations to complement the canonical stem cells in promoting repair following injury. Signaling pathways such as WNT, bone morphogenetic protein, and Sonic Hedgehog play critical roles in stem cell maintenance and cell fate decisions across diverse epithelia and conditions, suggesting that conserved mechanisms underlie the regenerative capacity of adult epithelial structures. This article is categorized under: Gene Expression and Transcriptional Hierarchies > Regulatory Mechanisms Adult Stem Cells, Tissue Renewal, and Regeneration > Tissue Stem Cells and Niches Adult Stem Cells, Tissue Renewal, and Regeneration > Stem Cell Differentiation and Reversion Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration
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页数：18
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