Genotoxicity of selected metal compounds in the SOS chromotest

被引：27

作者：

Lantzsch, H ^{[1
]}

Gebel, T ^{[1
]}

机构：

[1] UNIV GOTTINGEN,MED INST GEN HYG & ENVIRONM HLTH,D-37073 GOTTINGEN,GERMANY

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 1997年 / 389卷 / 2-3期

关键词：

SOS chromotest; metal genotoxicity; platinum; palladium; chromium(VI); rhodium;

D O I：

10.1016/S1383-5718(96)00146-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Knowledge concerning the genotoxicity of inorganic metal compounds in the SOS chromotest is limited. Up to now, only Cr(VI), Sn(II) and the platinum antitumor compound cisplatin(II) were shown to be genotoxic in this test system. However, for Cr(VI) and Sn(II), a positive reaction could only be achieved in cytotoxic dose ranges. The aim of the present study was to provide additional data concerning metal salt genotoxicity in the SOS chromotest. Therefore, 14 metal/metalloid salt compounds of platinum, palladium, rhodium, arsenic, antimony and chromium were tested. Four platinum salts, K2PtCl4, cis-Pt(NH3)(2)Cl-2 (cisplatin), trans-Pt(NH3)(2)Cl-2 (transplatin) and PtCl4 as well as two rhodium compounds tested, K2RhCl5 and (NH4)(3)RhCl6, could be shown to be genotoxic in the chromotest using the tester strain Escherichia coli PQ37. A moderate genotoxicity was shown by the two Cr(VI) compounds K2CrO4 and K2Cr2O7. All palladium compounds and all the other metal salts tested were unable to induce a significant SOS response.

引用

页码：191 / 197

页数：7

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