Sesquiterpenes and triterpenoids from the rhizomes of Alisma orientalis and their pancreatic lipase inhibitory activities

被引：27

作者：

Cang, Jian ^{[1
,2
]}

Wang, Chao ^{[1
]}

Huo, Xiao-Kui ^{[1
]}

Tian, Xiang-Ge ^{[1
]}

Sun, Cheng-Peng ^{[1
]}

Deng, Sa ^{[1
]}

Zhang, Bao-Jing ^{[1
]}

Zhang, Hou-Li ^{[1
]}

Liu, Ke-Xin ^{[1
]}

Ma, Xiao-Chi ^{[1
,2
]}

机构：

[1] Dalian Med Univ, Coll Pharm, Dalian, Peoples R China

[2] Dalian Med Univ, Acad Integrat Med, Dalian, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2017年 / 19卷

基金：

中国国家自然科学基金;

关键词：

Alisma orientalis; Sesquiterpenes; Triterpenoids; Pancreatic lipase; BIOLOGICAL-ACTIVE TRITERPENES; PROTOSTANE-TYPE TRITERPENES; ABSOLUTE STEREOSTRUCTURES; DRIED RHIZOME; CONSTITUENTS; EXTRACT; 23-ACETATE; ALISOLS;

D O I：

10.1016/j.phytol.2016.12.017

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new terpenoids, including three sesquiterpenes 11-hydroxy-8-ox-alismoxide (1), 11-oxo-13-noralismol (2), and 1 beta 11-dihydroxy-beta-cyperone (3), and two protostane-type triterpenoids 16 beta-acetoxy alisol B (4) and 16 alpha-acetoxy alisol B (5) were isolated from the rhizomes of Alisma orientalis together with 11 known compounds. Their structures were established using 1D and 2D NMR and HRESIMS spectroscopic analyses. The isolated compounds were assayed for their inhibitory activities against pancreatic lipase. Compounds 6 and 13 showed inhibitory effects with IC50 values of 64.4 and 45.5 mu M, respectively. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.

引用

页码：83 / 88

页数：6

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