Evaluation of an interferon gamma assay in the diagnosis of latent tuberculosis infection in patients with rheumatoid arthritis

被引：25

作者：

Lopes Marques, Claudia Diniz ^{[1
]}

Branco Pinto Duarte, Angela Luzia ^{[2
]}

Barros de Lorena, Virginia Maria ^{[3
]}

Souza, Joelma Rodrigues ^{[3
]}

Souza, Wayner Vieira ^{[3
]}

Gomes, Yara de Miranda ^{[3
]}

Freese de Carvalho, Eduardo Maia ^{[3
]}

机构：

[1] Escola Pernambucana Med, FBV IMIP, BR-50070550 Recife, PE, Brazil

[2] Univ Fed Pernambuco, Hosp Clin, Recife, PE, Brazil

[3] Fundacao Oswaldo Cruz Fiocruz, Ctr Pesquisas Aggeu Magalhaes, Recife, PE, Brazil

来源：

RHEUMATOLOGY INTERNATIONAL | 2009年 / 30卷 / 01期

关键词：

Rheumatoid arthritis; Tuberculosis; Diagnosis; Interferon-gamma assay; SKIN-TEST; MYCOBACTERIUM-TUBERCULOSIS; PREVALENCE; UTILITY; TESTS;

D O I：

10.1007/s00296-009-0910-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The tuberculin skin test is not an ideal screening test for the patients with rheumatoid arthritis to identify cases of latent tuberculosis infection (LTBI) prior to the start of treatment with anti-TNFs, as it responds inadequately to late hypersensitivity, which is fundamental for producing a response to the inoculated antigen. Assays based on detection of the production of IFN gamma in vitro by mononuclear peripheral cells stimulated by specific antigens are more specific than PPD in detecting LTBI. The aim of this study was to evaluate the performance of T-SPOT.TB in diagnosis of LTBI in patients with rheumatoid arthritis, comparing with the PPD. The specificity of the T-SPOT.TB varied from 87 to 90% and the negative-predictive value (NPV) from 94.4 to 100%. It can be concluded that the T-SPOT.TB showed high specificity and NPV, proving the capability of identifying false-negative cases of PPD, raising the level of safety for the use of anti-TNFs.

引用

页码：57 / 62

页数：6

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