On the magnetic field and isotope effects in enzymatic phosphorylation

被引：39

作者：

Buchachenko, Anatoly L.

Lukzen, Nikita N.

Pedersen, J. Boiden ^{[1
]}

机构：

[1] Univ So Denmark, Dept Chem & Phys, DK-5230 Odense M, Denmark

[2] Int Tomog Ctr, Novosibirsk 630090, Russia

[3] Russian Acad Sci, NN Semenov Chem Phys Inst, Moscow 119991, Russia

来源：

CHEMICAL PHYSICS LETTERS | 2007年 / 434卷 / 1-3期

关键词：

D O I：

10.1016/j.cplett.2006.12.019

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A huge magnesium isotope effect on the rate of enzymatic synthesis of adenosine triphosphate (ATP) has recently been reported. This indicates that the reaction involves an intermediate ion-radical pairs and should be sensitive to external magnetic fields. We have calculated the rate of ATP production based on a previously proposed molecular reaction mechanism. The calculated maximum isotope effect is in agreement with experiment. Magnetic field is predicted to increase the rate of ATP formation by 60% for samples enriched by magnetic magnesium (Mg-25) while decreasing the rate by 9% for naturally occurring samples. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：139 / 143

页数：5

共 13 条

[1] ESR-SPECTRUM AND STRUCTURE OF MGOH RADICAL [J].