High levels of cervical HIV-1 RNA during early HIV-1 infection

被引：7

作者：

Lavreys, Ludo ^{[1
]}

Baeten, Jared M.

Panteleeff, Dana D.

Richardson, Barbra A.

McClelland, R. Scott

Chohan, Varsha

Mandaliya, Kishorchandra

Ndinya-Achola, Jeckoniah O.

Overbaugh, Julie

机构：

[1] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Med, Seattle, WA 98195 USA

[3] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[4] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya

[5] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98104 USA

[6] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[7] Coast Gen Prov Hosp, Mombasa, Kenya

来源：

AIDS | 2006年 / 20卷 / 18期

关键词：

D O I：

10.1097/QAD.0b013e328010f1e7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Few data are available on genital tract viral replication early after HIV-1 acquisition, when infectivity is high. We compared cervical HIV-1 RNA from 60 women with paired samples from within 90 days after HIV-1 acquisition and at viral setpoint (4-24 months). Cervical HIV-1 was higher in early compared with setpoint samples (mean 3.43 versus 2.85 log(10) copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log(10) copies/swab (P = 0.006).

引用

页码：2389 / 2390

页数：2

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