Farnesoid X receptor: a potential therapeutic target in multiple organs

被引：16

作者：

Zhang, Chao ^{[1
]}

Wang, Zixuan ^{[1
]}

Feng, Qingqing ^{[1
]}

Chen, Wei-Dong ^{[2
,3
]}

Wang, Yan-Dong ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Chem Resource Engn, Beijing, Peoples R China

[2] Inner Mongolia Med Univ, Sch Basic Med Sci, Key Lab Mol Pathol, Hohhot, Inner Mongolia, Peoples R China

[3] Henan Univ, Peoples Hosp Hebi, Sch Med, Key Lab Receptors Mediated Gene Regulat & Drug Di, Kaifeng, Henan, Peoples R China

来源：

HISTOLOGY AND HISTOPATHOLOGY | 2020年 / 35卷 / 12期

关键词：

Farnesoid X receptor; Bile acid; Metabolic homeostasis; Signaling pathways; AGONIST OBETICHOLIC ACID; BILE-ACIDS; NUCLEAR RECEPTOR; BREAST-CANCER; PANCREATIC-CANCER; NONALCOHOLIC STEATOHEPATITIS; PROLIFERATION DEFECTS; PORTAL-HYPERTENSION; ESTROGEN-RECEPTOR; CELL-MIGRATION;

D O I：

10.14670/HH-18-301

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Farnesoid X receptor (FXR), a member of the nuclear receptor family, is a common receptor found in the intestine and liver, and helps to maintain systemic metabolic homeostasis through regulating bile acid, glucose, lipid metabolism, and energy homeostatsis. In addition, FXR regulates the functions of various organs, such as liver, intestine, kidney, breast, pancreas, cardiovascular system and brain. FXR also plays a key role in regulation of gut-microbiota through mediating the various signaling pathways. Accordingly, FXR has become an attractive therapeutic target in a variety of diseases. This review combines classical and recent research reports to introduce the basic information about FXR and its important roles in various organs of the body.

引用

页码：1403 / 1414

页数：12

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