Preparation and characterization of Tegafur magnetic thermosensitive liposomes

被引：6
作者：
Zeng Zhaowu [1 ,2 ,3 ]
Wang Xiaoli [4 ]
Zhang Yangde [1 ,2 ,3 ]
Liu Xingyan [1 ,2 ,3 ]
Zhou Weihua [1 ,2 ,3 ]
Li Nianfeng [1 ,2 ,3 ]
机构：
[1] Cent S Univ, Minist Hlth, Natl Hepatobiliary & Enter Surg Res Ctr, Changsha 410008, Hunan, Peoples R China
[2] Natl Key Lab Nanobiol Technol, Changsha, Hunan, Peoples R China
[3] Cent S Univ, Inst Biomed Engn, Changsha 410008, Hunan, Peoples R China
[4] Yichun Univ JiangXi Prov, Yichun, Jiangxi, Peoples R China
来源：
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2009年 / 14卷 / 04期
关键词：
Tegafur; magnetic; thermosensitive; liposome; DRUG-DELIVERY; IN-VIVO; MAGNETOLIPOSOMES; HYPERTHERMIA; NANOPARTICLES; SYSTEM;
D O I：
10.1080/10837450802647300
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purpose was to study the preparation and properties of tegafur magnetic thermosensitive liposomes. The method was to employ an improved chemical coprecipitation method for preparing nano-magnetic particles and a reverse-phase evaporation and ultrasonic method for preparing tegafur magnetic thermosensitive liposomes. The results showed that tegafur magnetic thermosensitive liposomes were prepared successfully. They had comparatively strong magnetism and superparamagnetism, and their temperature showed a linear positive correlation with dosages and the field strength under a current value. The conclusion was that tegafur magnetic thermosensitive liposomes with comparatively small particle size, superparamagnetism and comparatively strong magnetism were prepared successfully.
引用
收藏
页码：350 / 357
页数：8
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