Leprosy in Children

被引:23
作者
Barreto, Josafa Goncalves [1 ]
Cipriani Frade, Marco Andrey [2 ]
Bernardes Filho, Fred [2 ]
da Silva, Moises Batista [3 ]
Spencer, John Stewart [4 ]
Salgado, Claudio Guedes [3 ]
机构
[1] Fed Univ Para, Spatial Epidemiol Lab, Campus Castanhal,Ave Univ S-N, BR-68746360 Bairro Jaderlandia Casta, Para, Brazil
[2] Univ Sao Paulo, Dept Ribeirao Preto Med Sch, Div Dermatol Internal Med, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP, Brazil
[3] Fed Univ Para, Dermatoimmunol Lab, Av Joao Paulo II,113 Bairro Dom Aristides, BR-67200000 Marituba, Para, Brazil
[4] Colorado State Univ, Dept Microbiol Immunol & Pathol, 1682 Campus Delivery, Ft Collins, CO 80523 USA
关键词
Leprosy; Early diagnosis; Children; LATERAL FLOW ASSAY; CHILDHOOD LEPROSY; MYCOBACTERIUM-LEPRAE; CHEMOPROPHYLAXIS; COMBINATION; INFECTION; RATES; INDIA;
D O I
10.1007/s11908-017-0577-6
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Purpose of Review This manuscript aims to review the cutting-edge developments regarding to the diagnosis, management, and prevention of leprosy in children. Recent Findings Leprosy transmission still occurs continuously in some endemic areas in the world. Leprosy in children below 15 years old is a robust indicator of active source of infection in the community where they live. A special focus on children to reduce disabilities and reduce transmission is one of the core areas of interventions of the global leprosy strategy 2016-2020. Ongoing research is trying to develop better diagnostic tests and to advance chemoprophylaxis and immunoprophylaxis approaches. Summary Early diagnosis in children can be hard because of the wide range of clinical aspects of the skin lesions and mainly due to the difficulty of performing the clinical peripheral nerve evaluation. We must maintain leprosy expertise and improve the health professionals training for leprosy diagnosis, since we still have a long journey to reach leprosy elimination.
引用
收藏
页数:8
相关论文
共 46 条
[1]   Performance of general health workers in leprosy control activities at public health facilities in Amhara and Oromia States, Ethiopia [J].
Abeje, Tadiye ;
Negera, Edessa ;
Kebede, Eshetu ;
Hailu, Tsegaye ;
Hassen, Ismaile ;
Lema, Tsehainesh ;
Yamuah, Lawrence ;
Shiguti, Birru ;
Fenta, Melkamu ;
Negasa, Megersa ;
Beyene, Demissew ;
Bobosha, Kidist ;
Aseffa, Abraham .
BMC HEALTH SERVICES RESEARCH, 2016, 16
[2]   Serum Metabolomics Reveals Higher Levels of Polyunsaturated Fatty Acids in Lepromatous Leprosy: Potential Markers for Susceptibility and Pathogenesis [J].
Al-Mubarak, Reem ;
Vander Heiden, Jason ;
Broeckling, Corey D. ;
Balagon, Marivic ;
Brennan, Patrick J. ;
Vissa, Varalakshmi D. .
PLOS NEGLECTED TROPICAL DISEASES, 2011, 5 (09)
[3]  
[Anonymous], 2016, Global Leprosy Strategy 2016-2020
[4]   Molecular Evidence for the Aerial Route of Infection of Mycobacterium leprae and the Role of Asymptomatic Carriers in the Persistence of Leprosy [J].
Araujo, Sergio ;
Freitas, Larissa Oliveira ;
Goulart, Luiz Ricardo ;
Bernardes Goulart, Isabela Maria .
CLINICAL INFECTIOUS DISEASES, 2016, 63 (11) :1412-1420
[5]   Leprosy Diagnostic Test Development As a Prerequisite Towards Elimination: Requirements from the User's Perspective [J].
Bahmanyar, Edith Roset ;
Smith, William Cairns ;
Brennan, Patrick ;
Cummings, Ray ;
Duthie, Malcolm ;
Richardus, Jan Hendrik ;
Saunderson, Paul ;
Shwe, Tin ;
Rosen, Steven ;
Geluk, Annemieke .
PLOS NEGLECTED TROPICAL DISEASES, 2016, 10 (02)
[6]   Spatial epidemiology and serologic cohorts increase the early detection of leprosy [J].
Barreto, Josafa Goncalves ;
Bisanzio, Donal ;
Cipriani Frade, Marco Andrey ;
Pires Moraes, Tania Mara ;
Gobbo, Angelica Rita ;
de Souza Guimaraes, Layana ;
da Silva, Moises Batista ;
Vazquez-Prokopec, Gonzalo M. ;
Spencer, John Stewart ;
Kitron, Uriel ;
Salgado, Claudio Guedes .
BMC INFECTIOUS DISEASES, 2015, 15
[7]   Spatial Analysis Spotlighting Early Childhood Leprosy Transmission in a Hyperendemic Municipality of the Brazilian Amazon Region [J].
Barreto, Josafa Goncalves ;
Bisanzio, Donal ;
Guimaraes, Layana de Souza ;
Spencer, John Stewart ;
Vazquez-Prokopec, Gonzalo M. ;
Kitron, Uriel ;
Salgado, Claudio Guedes .
PLOS NEGLECTED TROPICAL DISEASES, 2014, 8 (02)
[8]   High rates of undiagnosed leprosy and subclinical infection amongst school children in the Amazon Region [J].
Barreto, Josafa Goncalves ;
Guimaraes, Layana de Souza ;
Cipriani Frade, Marco Andrey ;
Rosa, Patricia Sammarco ;
Salgado, Claudio Guedes .
MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2012, 107 :60-67
[9]   Field-Evaluation of a New Lateral Flow Assay for Detection of Cellular and Humoral Immunity against Mycobacterium leprae [J].
Bobosha, Kidist ;
Fat, Elisa M. Tjon Kon ;
van den Eeden, Susan J. F. ;
Bekele, Yonas ;
van der Ploeg-van Schip, Jolien J. ;
de Dood, Claudia J. ;
Dijkman, Karin ;
Franken, Kees L. M. C. ;
Wilson, Louis ;
Aseffa, Abraham ;
Spencer, John S. ;
Ottenhoff, Tom H. M. ;
Corstjens, Paul L. A. M. ;
Geluk, Annemieke .
PLOS NEGLECTED TROPICAL DISEASES, 2014, 8 (05)
[10]   Lateral flow assay for simultaneous detection of cellular- and humoral immune responses [J].
Corstjens, Paul L. A. M. ;
de Dood, Claudia J. ;
van der Ploeg-van Schip, Jolien J. ;
Wiesmeijer, Karien C. ;
Riuttamaki, Terhi ;
van Meijgaarden, Krista E. ;
Spencer, John S. ;
Tanke, Hans J. ;
Ottenhoff, Tom H. M. ;
Geluk, Annemieke .
CLINICAL BIOCHEMISTRY, 2011, 44 (14-15) :1241-1246