A bioluminescent sensor for highly selective and sensitive detection of human carboxylesterase 1 in complex biological samples

被引：89

作者：

Wang, Dan-Dan ^{[1
]}

Jin, Qiang ^{[1
]}

Zou, Li-Wei ^{[1
]}

Hou, Jie ^{[2
]}

Lv, Xia ^{[1
]}

Lei, Wei ^{[2
]}

Cheng, Hai-Ling ^{[3
]}

Ge, Guang-Bo ^{[1
]}

Yang, Ling ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China

[2] Dalian Med Univ, Dalian 116044, Peoples R China

[3] Dalian Med Univ, Hosp 2, Inst Canc, Dalian, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 15期

关键词：

IN-VIVO; CATALYTIC-PROPERTIES; GENETIC-VARIANTS; HUMAN LIVER; HYDROLYSIS; PROBE; OSELTAMIVIR; POLYMORPHISM; METABOLISM; ACTIVATION;

D O I：

10.1039/c5cc09874b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly selective and sensitive bioluminescent sensor (DME) for human carboxylesterase 1 (hCE1) has been developed and well characterized. DME could be used for real-time monitoring of hCE1 activities in complex biological samples and for bio-imaging of endogenous hCE1 in living cells.

引用

页码：3183 / 3186

页数：4

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