Toxicological evaluation of the essential oil of Piper aduncum L.

被引：31
|
作者：
Sousa, Pergentino J. C. [1 ]
Barros, Carlos A. L. [1 ]
Rocha, Jose Carlos S. [1 ]
Lira, Denisleia S. [1 ]
Monteiro, Gisele M. [1 ]
Maia, Jose Guilherme S. [2 ]
机构：
[1] Fed Univ Para, Ctr Ciencias Saude, Dept Farm, BR-66075110 Belem, Para, Brazil
[2] Fed Univ Para, Ctr Tecnol, Dept Engn Quim & Alimentos, BR-66075900 Belem, Para, Brazil
来源：
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2008年 / 18卷 / 02期
关键词：
Piper aduncum; Piperaceae; essential oil; acute toxicity; subacute toxicity;
D O I：
10.1590/S0102-695X2008000200013
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The aim of this work was the acute and subacute toxicological evaluation of the essential oil of Piper aduncum with the determination of the LD50 in mice and the analysis of their hematological and biochemical parameters in rats. The plant is used in the Amazon folk medicine for several diseases and the phenylpropanoid dilapiolle is the main constituent of its essential oil, possessing insecticidal, fungicidal, bactericidal, larvicidal and molluscicidal properties. The LD50 was 2.400 +/- 191,7 mg/kg. The essential oil did-not change the hematological and biochemical parameters in a significant manner when compared with the control in the subacute treatment; excepting the reduction of creatinine. The LD50 and the hematological and biochemical results have suggested that the essential oil presents low toxicity.
引用
收藏
页码：217 / 221
页数：5
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