Human epicardial fat: what is new and what is missing?

被引：100

作者：

Sacks, Harold S. ^{[1
]}

Fain, John N. ^{[2
]}

机构：

[1] VA Greater Los Angeles Healthcare Syst, Endocrinol & Diabet Div 111D, Los Angeles, CA 90073 USA

[2] Univ Tennessee, Dept Mol Sci, Hlth Sci Ctr, Memphis, TN USA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2011年 / 38卷 / 12期

关键词：

adipokines; coronary atherosclerosis; epicardial fat; genes; inflammation; PERIVASCULAR ADIPOSE-TISSUE; CORONARY-ARTERY-DISEASE; PERICARDIAL FAT; NONDIABETIC PATIENTS; COMPUTED-TOMOGRAPHY; METABOLIC SYNDROME; BARIATRIC SURGERY; GENE-EXPRESSION; SAPHENOUS-VEIN; WEIGHT-LOSS;

D O I：

10.1111/j.1440-1681.2011.05601.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Putative physiological functions of human epicardial adipose tissue (EAT) include: (i) lipid storage for the energy needs of the myocardium; (ii) thermoregulation, whereby brown fat components of EAT generate heat by non-shivering thermogenesis in response to core cooling; (iii) neuroprotection of the cardiac autonomic ganglia and nerves; and (iv) regulation of vasomotion and luminal size of the coronary arteries. Under pathophysiological circumstances, EAT may play an adverse paracrine role in cardiac arrhythmias and in lipotoxic cardiomyopathy, but of major current interest is its hypothetical role as an immunological organ contributing to inflammation around coronary artery disease (CAD).

引用

页码：879 / 887

页数：9

共 50 条

[41] Co-Cultivation of Human Aortic Smooth Muscle Cells With Epicardial Adipocytes Affects Their Proliferation Rate [J].

Zdychova, J. ;

Cejkova, S. ;

Lesna, I. Kralova ;

Kralova, A. ;

Maluskova, J. ;

Janousek, L. ;

Kazdova, L. .

PHYSIOLOGICAL RESEARCH, 2014, 63 :S419-S427

[42] Correlation of echocardiographic epicardial fat thickness with severity of coronary artery disease-an observational study [J].

Shemirani, Hasan ;

Khoshavi, Meysam .

ANATOLIAN JOURNAL OF CARDIOLOGY, 2012, 12 (03) :200-205

[43] Epicardial Fat in Heart Failure with Preserved Ejection Fraction: Bad Actor or Just Lying Around? [J].

Oduah, Mary-Tiffany ;

Sundaram, Varun ;

Reddy, Yogesh N., V .

CARDIAC FAILURE REVIEW, 2023, 9

[44] Effect of sitagliptin on epicardial fat thickness in subjects with type 2 diabetes and obesity: a pilot study [J].

Lima-Martinez, Marcos M. ;

Paoli, Mariela ;

Rodney, Marianela ;

Balladares, Nathalie ;

Contreras, Miguel ;

D'Marco, Luis ;

Iacobellis, Gianluca .

ENDOCRINE, 2016, 51 (03) :448-455

[45] Epicardial fat. Imaging and implications for diseases of the cardiovascular system [J].

Niemann, M. ;

Alkadhi, H. ;

Gotschy, A. ;

Kozerke, S. ;

Manka, R. .

HERZ, 2015, 40 :282-290

[46] The relationship between muscle strength and epicardial fat in healthy adults [J].

Komici, Klara ;

Bencivenga, Leonardo ;

Arganese, Caterina ;

Rengo, Giuseppe ;

Guerra, Germano .

EXPERIMENTAL GERONTOLOGY, 2024, 192

[47] Epicardial fat and coronary artery disease: Role of cardiac imaging [J].

Guglielmo, Marco ;

Lin, Andrew ;

Dey, Damini ;

Baggiano, Andrea ;

Fusini, Laura ;

Muscogiuri, Giuseppe ;

Pontone, Gianluca .

ATHEROSCLEROSIS, 2021, 321 :30-38

[48] Epicardial fat in heart failure-Friend, foe, or bystander [J].

Paterek, Aleksandra ;

Zaleska-Kociecka, Marta ;

Wojdynska, Zuzanna ;

Kalisz, Malgorzata ;

Litwiniuk, Anna ;

Leszek, Przemyslaw ;

Maczewski, Michal .

OBESITY REVIEWS, 2024, 25 (12)

[49] Simple quantification of paracardial and epicardial fat dimensions at low-dose chest CT: correlation with metabolic risk factors and usefulness in predicting metabolic syndrome [J].

Lim, Chaehun ;

Ahn, Myeong-Im ;

Jung, Jung Im ;

Beck, Kyongmin Sarah .

JAPANESE JOURNAL OF RADIOLOGY, 2018, 36 (09) :528-536

[50] The relationship between epicardial fat thickness and gestational diabetes mellitus [J].

Nar, Gokay ;

Inci, Sinan ;

Aksan, Gokhan ;

Unal, Oguz Kagan ;

Nar, Rukiye ;

Soylu, Korhan .

DIABETOLOGY & METABOLIC SYNDROME, 2014, 6

← 1 2 3 4 5 →