Human epicardial fat: what is new and what is missing?

被引：100

作者：

Sacks, Harold S. ^{[1
]}

Fain, John N. ^{[2
]}

机构：

[1] VA Greater Los Angeles Healthcare Syst, Endocrinol & Diabet Div 111D, Los Angeles, CA 90073 USA

[2] Univ Tennessee, Dept Mol Sci, Hlth Sci Ctr, Memphis, TN USA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2011年 / 38卷 / 12期

关键词：

adipokines; coronary atherosclerosis; epicardial fat; genes; inflammation; PERIVASCULAR ADIPOSE-TISSUE; CORONARY-ARTERY-DISEASE; PERICARDIAL FAT; NONDIABETIC PATIENTS; COMPUTED-TOMOGRAPHY; METABOLIC SYNDROME; BARIATRIC SURGERY; GENE-EXPRESSION; SAPHENOUS-VEIN; WEIGHT-LOSS;

D O I：

10.1111/j.1440-1681.2011.05601.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Putative physiological functions of human epicardial adipose tissue (EAT) include: (i) lipid storage for the energy needs of the myocardium; (ii) thermoregulation, whereby brown fat components of EAT generate heat by non-shivering thermogenesis in response to core cooling; (iii) neuroprotection of the cardiac autonomic ganglia and nerves; and (iv) regulation of vasomotion and luminal size of the coronary arteries. Under pathophysiological circumstances, EAT may play an adverse paracrine role in cardiac arrhythmias and in lipotoxic cardiomyopathy, but of major current interest is its hypothetical role as an immunological organ contributing to inflammation around coronary artery disease (CAD).

引用

页码：879 / 887

页数：9

共 75 条

[1] Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease [J].

Baker, Adam R. ;

da Silva, Nancy F. ;

Quinn, David W. ;

Harte, Alison L. ;

Pagano, Domenico ;

Bonser, Robert S. ;

Kumar, Sudhesh ;

McTernan, Philip G. .

CARDIOVASCULAR DIABETOLOGY, 2006, 5 (1)

[2]

Bambace C, 2010, CARDIOVASC PATHOL, V20, pe153

[3] The inflammatory hypothesis - Any progress in risk stratification and therapeutic targets? [J].

Blankenberg, Stefan ;

Yusuf, Salim .

CIRCULATION, 2006, 114 (15) :1557-1560

[4] Association of Pericardial Fat With Liver Fat and Insulin Sensitivity After Diet-Induced Weight Loss in Overweight Women [J].

Bosy-Westphal, Anja ;

Kossel, Elke ;

Goele, Kristin ;

Bloecker, Thordis ;

Lagerpusch, Merit ;

Later, Wiebke ;

Heller, Martin ;

Glueer, Claus C. ;

Mueller, Manfred J. .

OBESITY, 2010, 18 (11) :2111-2117

[5] Pericardial Fat Loss in Postmenopausal Women under Conditions of Equal Energy Deficit [J].

Brinkley, Tina E. ;

Ding, Jingzhong ;

Carr, J. Jeffrey ;

Nicklas, Barbara J. .

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2011, 43 (05) :808-814

[6] Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: a role for NGF and BDNF in cardiovascular disease? [J].

Chaldakov, GN ;

Fiore, M ;

Stankulov, IS ;

Manni, L ;

Hristova, MG ;

Antonelli, A ;

Ghenev, PI ;

Aloe, L .

NGF AND RELATED MOLECULES IN HEALTH AND DISEASE, 2004, 146 :279-289

[7] Subepicardial adipose tissue and the presence and severity of coronary artery disease [J].

Chaowalit, Nithima ;

Somers, Virend K. ;

Pellikka, Patricia A. ;

Rihal, Charanjit S. ;

Lopez-Jimenez, Francisco .

ATHEROSCLEROSIS, 2006, 186 (02) :354-359

[8] Proinflammatory Phenotype of Perivascular Adipocytes Influence of High-Fat Feeding [J].

Chatterjee, Tapan K. ;

Stoll, Lynn L. ;

Denning, Gerene M. ;

Harrelson, Allan ;

Blomkalns, Andra L. ;

Idelman, Gila ;

Rothenberg, Florence G. ;

Neltner, Bonnie ;

Romig-Martin, Sara A. ;

Dickson, Eric W. ;

Rudich, Steven ;

Weintraub, Neal L. .

CIRCULATION RESEARCH, 2009, 104 (04) :541-U237

[9] Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease [J].

Cheng, K-H ;

Chu, C-S ;

Lee, K-T ;

Lin, T-H ;

Hsieh, C-C ;

Chiu, C-C ;

Voon, W-C ;

Sheu, S-H ;

Lai, W-T .

INTERNATIONAL JOURNAL OF OBESITY, 2008, 32 (02) :268-274

[10] Pericardial Fat Burden on ECG-Gated Noncontrast CT in Asymptomatic Patients Who Subsequently Experience Adverse Cardiovascular Events [J].

Cheng, Victor Y. ;

Dey, Damini ;

Tamarappoo, Balaji ;

Nakazato, Ryo ;

Gransar, Heidi ;

Miranda-Peats, Romalisa ;

Ramesh, Amit ;

Wong, Nathan D. ;

Shaw, Leslee J. ;

Slomka, Piotr J. ;

Berman, Daniel S. .

JACC-CARDIOVASCULAR IMAGING, 2010, 3 (04) :352-360

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