Primary Hepatic Adenosquamous Carcinoma Associated with Primary Sclerosing Cholangitis

被引：14

作者：

Yamao, Kentaro ^{[1
]}

Takenaka, Mamoru ^{[1
]}

Imai, Hajime ^{[1
]}

Nakai, Atsushi ^{[1
]}

Omoto, Shunske ^{[1
]}

Kamata, Ken ^{[1
]}

Minaga, Kosuke ^{[1
]}

Miyata, Takeshi ^{[1
]}

Sakurai, Toshiharu ^{[1
]}

Watanabe, Tomohiro ^{[1
]}

Nishida, Naoshi ^{[1
]}

Matsumoto, Ippei ^{[2
]}

Takeyama, Yosihumi ^{[2
]}

Chikugo, Takaaki ^{[3
]}

Kudo, Masatoshi ^{[1
]}

机构：

[1] Kindai Univ, Fac Med, Dept Gastroenterol & Hepatol, 377-2 Ohno Higashi, Osaka, Osaka 5898511, Japan

[2] Kindai Univ, Fac Med, Dept Surg, Osaka, Japan

[3] Kindai Univ, Fac Med, Dept Pathol, Osaka, Japan

来源：

ONCOLOGY | 2017年 / 93卷

关键词：

Adenosquamous carcinoma; Primary sclerosing cholangitis; Liver tumor; Cholangiocarcinoma; Liver abscess; Ulcerative colitis; INTRAHEPATIC CHOLANGIOCARCINOMA; LIVER; MALIGNANCIES; RESECTION; JAPAN;

D O I：

10.1159/000481236

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disorder characterized by multiple fibrotic strictures of the bile duct. More than 40% of deaths in PSC patients are related to malignant tumors, including cholangiocarcinoma. Primary hepatic adenosquamous carcinoma (ASC) is a rare subtype of cholangiocarcinoma containing adenocarcinoma (AC) and squamous cell carcinoma (SCC) components, with a poorer prognosis than other cholangiocarcinomas. We report the first case of a hepatic ASC in a patient with PSC. Case Report: A 28-year-old man was referred for diagnosis and treatment of a liver abscess suspected by contrast-enhanced computed tomography (CECT). He had a history of ulcerative colitis and PSC. Abdominal CE-CT revealed a 60-mm-diameter ring-shaped mass with central necrosis in the left lobe. Magnetic resonance imaging demonstrated a poorly circumscribed low-signal-intensity mass in T1-weighted imaging and a high-signal-intensity mass with a scattered low-signal-intensity area in T2-weighted imaging. Abdominal ultrasonography showed a hypoechoic component with a diffuse hyperechoic area in the tumor. Ultrasound-guided biopsy and histological examination showed tumor cells with both squamous and glandular differentiation. Left lobectomy was performed. Microscopic examination revealed 2 components, including moderately differentiated AC and well-differentiated SCC. The final diagnosis was hepatic ASC. Conclusion: This is the first reported case of hepatic ASC in a patient with PSC. Patients with PSC should be recognized as being at a risk of not only general cholangiocarcinoma, hepatocellular carcinoma, and metastatic liver tumor, but also ASC. (c) 2017 S. Karger AG, Basel

引用

页码：76 / 80

页数：5

共 20 条

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