Gold nanoparticles as a label-free probe for the detection of amyloidogenic protein

被引：20

作者：

Zhang, Hai-Jie ^{[1
]}

Zheng, Hu-Zhi ^{[1
]}

Long, Yi-Juan ^{[1
]}

Xiao, Geng-Fu ^{[2
]}

Zhang, Ling-Yan ^{[1
]}

Wang, Qin-Long ^{[1
]}

Gao, Mei ^{[1
]}

Bai, Wen-Jun ^{[1
]}

机构：

[1] Southwest Univ, Coll Chem & Chem Engn, Chongqing 400715, Peoples R China

[2] Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China

来源：

TALANTA | 2012年 / 89卷

基金：

中国国家自然科学基金;

关键词：

Amyloidogenic protein; Gold nanoparticle; Prion protein; Label-free detection; CREUTZFELDT-JAKOB-DISEASE; PRION PROTEIN; CAPILLARY-ELECTROPHORESIS; COLORIMETRIC DETECTION; CEREBROSPINAL-FLUID; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; QUANTUM DOTS; BLOOD;

D O I：

10.1016/j.talanta.2011.12.052

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Because amyloidogenic proteins, such as prion protein, beta-amyloid peptide and alpha-synuclein, are associated with a variety of diseases, methods for their detection are important. Recombinant prion protein (rPrP) can selectively induce aggregation of dihydrolipoic acid capped gold nanoparticles (DHLA-AuNPs), which reduces the absorbance of the DHLA-AuNPs and changes their color from red to blue. These changes were used for label-free qualitative and quantitative detection of amyloidogenic protein. The addition of NaCl improved the detection sensitivity considerably, and the detection limit was as low as 33 pmol/L. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：401 / 406

页数：6

共 50 条

[41] A Label-Free Gold Nanocluster Fluorescent Probe for Protease Activity Monitoring
Zhang, Jiajing
Zhang, Zhen
Nie, Xin
Zhang, Zhenjiang
Wu, Xiaochun
Chen, Chunying
Fang, Xiaohong
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2014, 14 (06) : 4029 - 4035
[42] Label-free detection and manipulation of single biological nanoparticles
DeSantis, Michael C.
Cheng, Wei
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2016, 8 (05) : 717 - 729
[43] In Situ Label-Free Study of Protein Adsorption on Nanoparticles
Bernhard, Christoph
Van Zadel, Marc-Jan
Bunn, Alexander
Bonn, Mischa
Gonella, Grazia
JOURNAL OF PHYSICAL CHEMISTRY B, 2021, 125 (31): : 9019 - 9026
[44] Label-free aptamer-based colorimetric detection of mercury ions in aqueous media using unmodified gold nanoparticles as colorimetric probe
Li, Li
Li, Baoxin
Qi, Yingying
Jin, Yan
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2009, 393 (08) : 2051 - 2057
[45] Label-free aptamer-based colorimetric detection of mercury ions in aqueous media using unmodified gold nanoparticles as colorimetric probe
Li Li
Baoxin Li
Yingying Qi
Yan Jin
Analytical and Bioanalytical Chemistry, 2009, 393 : 2051 - 2057
[46] Label-free electrochemical biosensor based on dual amplification of gold nanoparticles and polycaprolactones for CEA detection
Wang, Xia
Qin, Zhe
Zhang, Fei
Li, Chong
Yuan, Xianxian
Yang, Jing
Yang, Huaixia
TALANTA, 2024, 278
[47] Label-Free Detection of Ag+ Based on Gold Nanoparticles and Ag+-Specific DNA
Pu, Wendan
Zhao, Zhao
Wu, Liping
Liu, Yue
Zhao, Huawen
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2015, 15 (08) : 5524 - 5529
[48] In situ SERS detection of emulsifiers at lipid interfaces using label-free amphiphilic gold nanoparticles
Li, Yue
Driver, Michael
Winuprasith, Thunnalin
Zheng, Jinkai
McClements, David Julian
He, Lili
ANALYST, 2014, 139 (20) : 5075 - 5078
[49] Label-free and naked eye detection of PNA/DNA hybridization using enhancement of gold nanoparticles
Kim, Sang Kyu
Cho, Hyunmin
Jeong, Jinyoung
Kwon, Ji Na
Jung, Yongwon
Chung, Bong Hyun
CHEMICAL COMMUNICATIONS, 2010, 46 (19) : 3315 - 3317
[50] Label-free optical detection of single-base mismatches by the combination of nuclease and gold nanoparticles
Liu, Meiying
Yuan, Min
Lou, Xinhui
Mao, Hongju
Zheng, Dongmei
Zou, Ruxing
Zou, Nengli
Tang, Xiangrong
Zhao, Jianlong
BIOSENSORS & BIOELECTRONICS, 2011, 26 (11): : 4294 - 4300

← 1 2 3 4 5 →