Gold nanoparticles as a label-free probe for the detection of amyloidogenic protein

被引：20

作者：

Zhang, Hai-Jie ^{[1
]}

Zheng, Hu-Zhi ^{[1
]}

Long, Yi-Juan ^{[1
]}

Xiao, Geng-Fu ^{[2
]}

Zhang, Ling-Yan ^{[1
]}

Wang, Qin-Long ^{[1
]}

Gao, Mei ^{[1
]}

Bai, Wen-Jun ^{[1
]}

机构：

[1] Southwest Univ, Coll Chem & Chem Engn, Chongqing 400715, Peoples R China

[2] Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China

来源：

TALANTA | 2012年 / 89卷

基金：

中国国家自然科学基金;

关键词：

Amyloidogenic protein; Gold nanoparticle; Prion protein; Label-free detection; CREUTZFELDT-JAKOB-DISEASE; PRION PROTEIN; CAPILLARY-ELECTROPHORESIS; COLORIMETRIC DETECTION; CEREBROSPINAL-FLUID; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; QUANTUM DOTS; BLOOD;

D O I：

10.1016/j.talanta.2011.12.052

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Because amyloidogenic proteins, such as prion protein, beta-amyloid peptide and alpha-synuclein, are associated with a variety of diseases, methods for their detection are important. Recombinant prion protein (rPrP) can selectively induce aggregation of dihydrolipoic acid capped gold nanoparticles (DHLA-AuNPs), which reduces the absorbance of the DHLA-AuNPs and changes their color from red to blue. These changes were used for label-free qualitative and quantitative detection of amyloidogenic protein. The addition of NaCl improved the detection sensitivity considerably, and the detection limit was as low as 33 pmol/L. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：401 / 406

页数：6

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