Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions

被引：14

作者：

Dowall, S. D. ^{[1
]}

Graham, V. A. ^{[1
]}

Corbin-Lickfett, K. ^{[2
]}

Empig, C. ^{[2
]}

Schlunegger, K. ^{[2
]}

Bruce, C. B. ^{[1
]}

Easterbrook, L. ^{[1
]}

Hewson, R. ^{[1
]}

机构：

[1] Publ Hlth England, Salisbury SP4 0JG, Wilts, England

[2] Peregrine Pharmaceut Inc, Tustin, CA 92780 USA

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2015年 / 2015卷

关键词：

TUMOR BLOOD-VESSELS; HEMORRHAGIC-FEVER VIRUSES; ANIONIC PHOSPHOLIPIDS; MONOCLONAL-ANTIBODY; NONHUMAN-PRIMATES; LIPID RAFTS; POSTEXPOSURE PROTECTION; APOPTOTIC MIMICRY; EXPRESSION; MEMBRANE;

D O I：

10.1155/2015/347903

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity. Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells. Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus.

引用

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