Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions

被引:14
作者
Dowall, S. D. [1 ]
Graham, V. A. [1 ]
Corbin-Lickfett, K. [2 ]
Empig, C. [2 ]
Schlunegger, K. [2 ]
Bruce, C. B. [1 ]
Easterbrook, L. [1 ]
Hewson, R. [1 ]
机构
[1] Publ Hlth England, Salisbury SP4 0JG, Wilts, England
[2] Peregrine Pharmaceut Inc, Tustin, CA 92780 USA
关键词
TUMOR BLOOD-VESSELS; HEMORRHAGIC-FEVER VIRUSES; ANIONIC PHOSPHOLIPIDS; MONOCLONAL-ANTIBODY; NONHUMAN-PRIMATES; LIPID RAFTS; POSTEXPOSURE PROTECTION; APOPTOTIC MIMICRY; EXPRESSION; MEMBRANE;
D O I
10.1155/2015/347903
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity. Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells. Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus.
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页数:9
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