Modulation of glutamate receptor expression by gonadal steroid hormones in the rat striatum

被引：12

作者：

D'Souza, DN

Harlan, RE

Garcia, MM

机构：

[1] Tulane Univ, Sch Med, Neurosci Program, New Orleans, LA 70112 USA

[2] Tulane Univ, Sch Med, Dept Struct & Cellular Biol, New Orleans, LA 70112 USA

[3] Tulane Univ, Sch Med, Dept Otolaryngol, New Orleans, LA 70112 USA

来源：

BRAIN RESEARCH BULLETIN | 2003年 / 59卷 / 04期

关键词：

immediate-early genes; gonadal hormones; glutamate receptors; morphine;

D O I：

10.1016/S0361-9230(02)00885-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) attenuates morphine-induced immediate-early gene expression in the rat striatum in a sexually dimorphic manner that depends in part on gonadal steroids. To determine if this effect was dependent on modulation of glutamate receptor gene expression, we studied the effect of gonadal hormones on levels of the NR1 subunit of NMDA receptor and the GluR2 subunit of the AMPA-subtype of glutamate receptor in the rat striatum, using autoradiographic immunocytochemistry. We found that ovariectomy decreased GluR2 immunoreactivity in the striatum, but no changes were seen in levels of NR1 following gonadectomy in either sex. Thus, the effects of gonadal steroids on NMDA receptor-mediated responses are not due to regulation of NR1 expression. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：289 / 292

页数：4

共 32 条

[1] N-methyl-D-aspartate receptor mRNA levels change during reproductive senescence in the hippocampus of female rats [J].